PMID- 23497940
OWN - NLM
STAT- MEDLINE
DCOM- 20130611
LR  - 20211021
IS  - 1096-0341 (Electronic)
IS  - 0042-6822 (Print)
IS  - 0042-6822 (Linking)
VI  - 440
IP  - 1
DP  - 2013 May 25
TI  - Canine and feline parvoviruses preferentially recognize the non-human cell 
      surface sialic acid N-glycolylneuraminic acid.
PG  - 89-96
LID - S0042-6822(13)00095-0 [pii]
LID - 10.1016/j.virol.2013.02.009 [doi]
AB  - Feline panleukopenia virus (FPV) is a pathogen whose canine-adapted form (canine 
      parvovirus (CPV)) emerged in 1978. These viruses infect by binding host 
      transferrin receptor type-1 (TfR), but also hemagglutinate erythrocytes. We show 
      that hemagglutination involves selective recognition of the non-human sialic acid 
      N-glycolylneuraminic acid (Neu5Gc) but not N-acetylneuraminic acid (Neu5Ac), 
      which differs by only one oxygen atom from Neu5Gc. Overexpression of alpha2-6 
      sialyltransferase did not change binding, indicating that both alpha2-3 and alpha2-6 
      linkages are recognized. However, Neu5Gc expression on target cells did not 
      enhance CPV or FPV infection in vitro. Thus, the conserved Neu5Gc-binding 
      preference of these viruses likely plays a role in the natural history of the 
      virus in vivo. Further studies must clarify relationships between virus infection 
      and host Neu5Gc expression. As a first step, we show that transcripts of CMAH 
      (which generates Neu5Gc from Neu5Ac) are at very low levels in Western dog breed 
      cells.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Lofling, Jonas
AU  - Lofling J
AD  - Department of Medicine, Center for Academic Research and Training in 
      Anthropogeny, 9500 Gilman Drive, University of California, San Diego, La Jolla, 
      CA 92093, USA.
FAU - Lyi, Sangbom Michael
AU  - Lyi SM
FAU - Parrish, Colin R
AU  - Parrish CR
FAU - Varki, Ajit
AU  - Varki A
LA  - eng
GR  - R01 AI028385/AI/NIAID NIH HHS/United States
GR  - R01 AI092571/AI/NIAID NIH HHS/United States
GR  - R01CA38701/CA/NCI NIH HHS/United States
GR  - R01 GM032373/GM/NIGMS NIH HHS/United States
GR  - R01GM32373/GM/NIGMS NIH HHS/United States
GR  - R01AI033486/AI/NIAID NIH HHS/United States
GR  - R01 CA038701/CA/NCI NIH HHS/United States
GR  - R01AI028385/AI/NIAID NIH HHS/United States
GR  - R01 GM080533/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20130314
PL  - United States
TA  - Virology
JT  - Virology
JID - 0110674
RN  - 0 (Neuraminic Acids)
RN  - 1113-83-3 (N-glycolylneuraminic acid)
SB  - IM
MH  - Animals
MH  - Cats
MH  - Dogs
MH  - Erythrocytes/virology
MH  - Feline Panleukopenia Virus/*metabolism
MH  - Gene Expression Regulation, Viral
MH  - Humans
MH  - Macaca mulatta/blood
MH  - Neuraminic Acids/chemistry/*metabolism
MH  - Pan troglodytes
MH  - Parvovirus, Canine/*metabolism
MH  - Species Specificity
MH  - Virus Attachment
PMC - PMC3634669
MID - NIHMS458548
EDAT- 2013/03/19 06:00
MHDA- 2013/06/12 06:00
PMCR- 2014/05/25
CRDT- 2013/03/19 06:00
PHST- 2012/12/14 00:00 [received]
PHST- 2013/02/12 00:00 [revised]
PHST- 2013/02/13 00:00 [accepted]
PHST- 2013/03/19 06:00 [entrez]
PHST- 2013/03/19 06:00 [pubmed]
PHST- 2013/06/12 06:00 [medline]
PHST- 2014/05/25 00:00 [pmc-release]
AID - S0042-6822(13)00095-0 [pii]
AID - 10.1016/j.virol.2013.02.009 [doi]
PST - ppublish
SO  - Virology. 2013 May 25;440(1):89-96. doi: 10.1016/j.virol.2013.02.009. Epub 2013 
      Mar 14.