PMID- 2349804
OWN - NLM
STAT- MEDLINE
DCOM- 19900712
LR  - 20131121
IS  - 0049-8254 (Print)
IS  - 0049-8254 (Linking)
VI  - 20
IP  - 5
DP  - 1990 May
TI  - Identification of metabolites of the 1",1"-dimethylheptyl analogue of cannabidiol 
      in rat and dog in vivo.
PG  - 447-55
AB  - 1. Metabolism of the 1",1"-dimethylheptyl analogue of cannabidiol (DMH-CBD) was 
      studied using an isolated perfused rat liver preparation and in rat and dog 
      urine. 2. Metabolites were identified using g.l.c.-mass spectrometry of the 
      trimethylsilyl (TMS), methyl ester/TMS and [2H9]TMS derivatives. 3. In contrast 
      with the metabolism of cannabidiol, the dimethylheptyl analogue gave low 
      concentrations of metabolites in all media examined. 4. Four metabolites were 
      found in the perfusion fluid. Two were identified as 6- and 7-hydroxy-DMH-CBD and 
      the other two were found to be hydroxylated in the dimethylheptyl chain but at 
      undetermined positions. 5. Five metabolites were identified in dog urine; these 
      were the 6- and 7-mono-hydroxy and 6,7-dihydroxy derivatives of acids formed by 
      one stage of beta-oxidation of the dimethylheptyl chain, and the 6- and 7-hydroxy 
      derivatives of corresponding acids formed by loss of three carbon atoms from the 
      chain. 6. Metabolic routes were very similar to those found earlier for 
      cannabidiol.
FAU - Samara, E
AU  - Samara E
AD  - Department of Pharmacy, Hebrew University of Jerusalem, Israel.
FAU - Bialer, M
AU  - Bialer M
FAU - Bar-On, H
AU  - Bar-On H
FAU - Harvey, D J
AU  - Harvey DJ
LA  - eng
GR  - DA04005/DA/NIDA NIH HHS/United States
GR  - Wellcome Trust/United Kingdom
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Xenobiotica
JT  - Xenobiotica; the fate of foreign compounds in biological systems
JID - 1306665
RN  - 0 (Cannabinoids)
RN  - 19GBJ60SN5 (Cannabidiol)
RN  - 97452-63-6 (5-(1,1-dimethylheptyl)cannabidiol)
SB  - IM
MH  - Animals
MH  - Cannabidiol/analogs & derivatives/*metabolism/urine
MH  - Cannabinoids/*metabolism
MH  - Dogs
MH  - Gas Chromatography-Mass Spectrometry
MH  - Hydroxylation
MH  - Liver/metabolism
MH  - Molecular Structure
MH  - Rats
EDAT- 1990/05/01 00:00
MHDA- 1990/05/01 00:01
CRDT- 1990/05/01 00:00
PHST- 1990/05/01 00:00 [pubmed]
PHST- 1990/05/01 00:01 [medline]
PHST- 1990/05/01 00:00 [entrez]
AID - 10.3109/00498259009046860 [doi]
PST - ppublish
SO  - Xenobiotica. 1990 May;20(5):447-55. doi: 10.3109/00498259009046860.