PMID- 23498686
OWN - NLM
STAT- MEDLINE
DCOM- 20130917
LR  - 20131121
IS  - 1873-4324 (Electronic)
IS  - 0003-2670 (Linking)
VI  - 770
DP  - 2013 Apr 3
TI  - A novel sensor based on electropolymerization of beta-cyclodextrin and L-arginine on 
      carbon paste electrode for determination of fluoroquinolones.
PG  - 53-61
LID - S0003-2670(13)00200-6 [pii]
LID - 10.1016/j.aca.2013.01.052 [doi]
AB  - An electrochemical sensor for fluoroquinolones (FQs) based on polymerization of 
      beta-cyclodextrin (beta-CD) and L-arginine (L-arg) modified carbon paste electrode 
      (CPE) (P-beta-CD-L-arg/CPE) was built for the first time. Synergistic effect of 
      L-arg and beta-CD was used to construct this sensor for quantification of these 
      important antibiotics. Scanning electron microscope (SEM) image shows that 
      polymer of beta-CD and L-arg has been successfully modified on electrode. 
      Electrochemical impedance spectroscopy (EIS) and cyclic voltammograms (CV) 
      further indicate that polymer of beta-CD and L-arg efficiently decreased the charge 
      transfer resistance value of electrode and improved the electron transfer kinetic 
      between analyte and electrode. Under the optimized conditions, this modified 
      electrode was utilized to determine the concentrations of ciprofloxacin, 
      ofloxacin, norfloxacin and gatifloxacin. The differential pulse voltammogram 
      (DPV) exhibits the oxidation peak currents were linearly proportional to their 
      concentration in the range of 0.05-100 muM for ciprofloxacin, 0.1-100 muM for 
      ofloxacin, 0.1-40 muM for norfloxacin and 0.06-100 muM for gatifloxacin, 
      respectively. This method was also successfully used to detect the concentrations 
      of each drug in pharmaceutical formulations and human serum samples. In addition, 
      this proposed fluoroquinolones sensor exhibited good reproducibility, long-term 
      stability and fast current response.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Zhang, Fenfen
AU  - Zhang F
AD  - School of Materials Science and Engineering, Shanghai University, Shanghai 
      200444, PR China.
FAU - Gu, Shuqing
AU  - Gu S
FAU - Ding, Yaping
AU  - Ding Y
FAU - Zhang, Zhen
AU  - Zhang Z
FAU - Li, Li
AU  - Li L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130208
PL  - Netherlands
TA  - Anal Chim Acta
JT  - Analytica chimica acta
JID - 0370534
RN  - 0 (Acids)
RN  - 0 (Fluoroquinolones)
RN  - 0 (beta-Cyclodextrins)
RN  - 5E8K9I0O4U (Ciprofloxacin)
RN  - 7440-44-0 (Carbon)
RN  - 94ZLA3W45F (Arginine)
SB  - IM
MH  - Acids/chemistry
MH  - Arginine/*chemistry
MH  - Blood Chemical Analysis
MH  - Carbon/*chemistry
MH  - Ciprofloxacin/chemistry
MH  - Drug Stability
MH  - *Electrochemistry
MH  - Electrodes
MH  - Fluoroquinolones/*analysis
MH  - Humans
MH  - Microscopy, Electron, Scanning
MH  - Molecular Structure
MH  - Polymerization
MH  - Reproducibility of Results
MH  - beta-Cyclodextrins/blood/*chemistry
EDAT- 2013/03/19 06:00
MHDA- 2013/09/18 06:00
CRDT- 2013/03/19 06:00
PHST- 2012/12/14 00:00 [received]
PHST- 2013/01/24 00:00 [revised]
PHST- 2013/01/28 00:00 [accepted]
PHST- 2013/03/19 06:00 [entrez]
PHST- 2013/03/19 06:00 [pubmed]
PHST- 2013/09/18 06:00 [medline]
AID - S0003-2670(13)00200-6 [pii]
AID - 10.1016/j.aca.2013.01.052 [doi]
PST - ppublish
SO  - Anal Chim Acta. 2013 Apr 3;770:53-61. doi: 10.1016/j.aca.2013.01.052. Epub 2013 
      Feb 8.