PMID- 23499443
OWN - NLM
STAT- MEDLINE
DCOM- 20130917
LR  - 20171116
IS  - 2211-1247 (Electronic)
VI  - 3
IP  - 3
DP  - 2013 Mar 28
TI  - Liver-primed memory T cells generated under noninflammatory conditions provide 
      anti-infectious immunity.
PG  - 779-95
LID - S2211-1247(13)00067-3 [pii]
LID - 10.1016/j.celrep.2013.02.008 [doi]
AB  - Development of CD8(+) T cell (CTL) immunity or tolerance is linked to the 
      conditions during T cell priming. Dendritic cells (DCs) matured during 
      inflammation generate effector/memory T cells, whereas immature DCs cause T cell 
      deletion/anergy. We identify a third outcome of T cell priming in absence of 
      inflammation enabled by cross-presenting liver sinusoidal endothelial cells. Such 
      priming generated memory T cells that were spared from deletion by immature DCs. 
      Similar to central memory T cells, liver-primed T cells differentiated into 
      effector CTLs upon antigen re-encounter on matured DCs even after prolonged 
      absence of antigen. Their reactivation required combinatorial signaling through 
      the TCR, CD28, and IL-12R and controlled bacterial and viral infections. Gene 
      expression profiling identified liver-primed T cells as a distinct 
      Neuropilin-1(+) memory population. Generation of liver-primed memory T cells may 
      prevent pathogens that avoid DC maturation by innate immune escape from also 
      escaping adaptive immunity through attrition of the T cell repertoire.
CI  - Copyright (c) 2013 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Bottcher, Jan P
AU  - Bottcher JP
AD  - Institutes of Molecular Medicine and Experimental Immunology, Rheinische 
      Friedrich-Wilhelms-Universitat, 53105 Bonn, Germany.
FAU - Schanz, Oliver
AU  - Schanz O
FAU - Wohlleber, Dirk
AU  - Wohlleber D
FAU - Abdullah, Zeinab
AU  - Abdullah Z
FAU - Debey-Pascher, Svenja
AU  - Debey-Pascher S
FAU - Staratschek-Jox, Andrea
AU  - Staratschek-Jox A
FAU - Hochst, Bastian
AU  - Hochst B
FAU - Hegenbarth, Silke
AU  - Hegenbarth S
FAU - Grell, Jessica
AU  - Grell J
FAU - Limmer, Andreas
AU  - Limmer A
FAU - Atreya, Imke
AU  - Atreya I
FAU - Neurath, Markus F
AU  - Neurath MF
FAU - Busch, Dirk H
AU  - Busch DH
FAU - Schmitt, Edgar
AU  - Schmitt E
FAU - van Endert, Peter
AU  - van Endert P
FAU - Kolanus, Waldemar
AU  - Kolanus W
FAU - Kurts, Christian
AU  - Kurts C
FAU - Schultze, Joachim L
AU  - Schultze JL
FAU - Diehl, Linda
AU  - Diehl L
FAU - Knolle, Percy A
AU  - Knolle PA
LA  - eng
SI  - GEO/GSE27139
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130314
PL  - United States
TA  - Cell Rep
JT  - Cell reports
JID - 101573691
RN  - 0 (CD28 Antigens)
RN  - 0 (Receptors, Antigen, T-Cell)
RN  - 0 (Receptors, Interleukin-12)
RN  - 144713-63-3 (Neuropilin-1)
SB  - IM
MH  - Animals
MH  - CD28 Antigens/immunology
MH  - CD8-Positive T-Lymphocytes/*immunology
MH  - Cross-Priming
MH  - Dendritic Cells/immunology
MH  - Endothelial Cells/immunology
MH  - Gene Expression Profiling
MH  - Immunity, Innate
MH  - *Immunologic Memory
MH  - Listeria monocytogenes/immunology
MH  - Liver/cytology/*immunology/microbiology
MH  - *Lymphocyte Activation
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neuropilin-1/genetics/metabolism
MH  - Receptors, Antigen, T-Cell/immunology
MH  - Receptors, Interleukin-12/immunology
EDAT- 2013/03/19 06:00
MHDA- 2013/09/18 06:00
CRDT- 2013/03/19 06:00
PHST- 2012/08/30 00:00 [received]
PHST- 2012/12/20 00:00 [revised]
PHST- 2013/02/05 00:00 [accepted]
PHST- 2013/03/19 06:00 [entrez]
PHST- 2013/03/19 06:00 [pubmed]
PHST- 2013/09/18 06:00 [medline]
AID - S2211-1247(13)00067-3 [pii]
AID - 10.1016/j.celrep.2013.02.008 [doi]
PST - ppublish
SO  - Cell Rep. 2013 Mar 28;3(3):779-95. doi: 10.1016/j.celrep.2013.02.008. Epub 2013 
      Mar 14.