PMID- 23499750
OWN - NLM
STAT- MEDLINE
DCOM- 20140110
LR  - 20130426
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Linking)
VI  - 56
DP  - 2013 Jun
TI  - Proanthocyanidins are the major anti-diabetic components of cinnamon water 
      extract.
PG  - 398-405
LID - S0278-6915(13)00158-0 [pii]
LID - 10.1016/j.fct.2013.02.049 [doi]
AB  - Cinnamon consumption has been found to associate with the attenuation of diabetes 
      mellitus. The misfolding of human islet amyloid polypeptide (hIAPP) is regarded 
      as a causative factor of type 2 diabetes mellitus (T2DM). Here, we investigated 
      whether cinnamon has any beneficial effect on the toxic aggregation of hIAPP. We 
      found that cinnamon water extract (CWE) inhibited the amyloid formation of hIAPP 
      in a dose-dependent manner, and identified proanthocyanidins as the major 
      anti-amyloidogenic compounds of CWE. Proanthocyanidins affected the secondary 
      structures of hIAPP and delayed the structural transition from unstructured coils 
      to beta-sheet-rich structures. Further studies showed that proanthocyanidins not 
      only inhibited the formation of hIAPP oligomers, but also significantly 
      attenuated the membrane damaging and cytotoxic effects caused by the hIAPP 
      aggregation. Together, these results suggest a possible way by which cinnamon 
      shows beneficial effects on T2DM, and indicate a potential pharmacological usage 
      of proanthocyanidins as an anti-diabetic drug candidate.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Jiao, Lihua
AU  - Jiao L
AD  - Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 
      430030, PR China.
FAU - Zhang, Xin
AU  - Zhang X
FAU - Huang, Lianqi
AU  - Huang L
FAU - Gong, Hao
AU  - Gong H
FAU - Cheng, Biao
AU  - Cheng B
FAU - Sun, Yue
AU  - Sun Y
FAU - Li, Yixuan
AU  - Li Y
FAU - Liu, Qi
AU  - Liu Q
FAU - Zheng, Ling
AU  - Zheng L
FAU - Huang, Kun
AU  - Huang K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130307
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Islet Amyloid Polypeptide)
RN  - 0 (Plant Extracts)
RN  - 0 (Proanthocyanidins)
RN  - 059QF0KO0R (Water)
SB  - IM
MH  - Cinnamomum zeylanicum/*chemistry
MH  - Circular Dichroism
MH  - Diabetes Mellitus, Type 2/pathology
MH  - Humans
MH  - Hypoglycemic Agents/chemistry/*pharmacology
MH  - Insulin-Secreting Cells/drug effects
MH  - Islet Amyloid Polypeptide/antagonists & inhibitors/chemistry
MH  - Microscopy, Electron, Transmission
MH  - Plant Extracts/*pharmacology
MH  - Proanthocyanidins/chemistry/*pharmacology
MH  - Protein Structure, Secondary
MH  - Water/chemistry
EDAT- 2013/03/19 06:00
MHDA- 2014/01/11 06:00
CRDT- 2013/03/19 06:00
PHST- 2013/01/03 00:00 [received]
PHST- 2013/02/24 00:00 [revised]
PHST- 2013/02/26 00:00 [accepted]
PHST- 2013/03/19 06:00 [entrez]
PHST- 2013/03/19 06:00 [pubmed]
PHST- 2014/01/11 06:00 [medline]
AID - S0278-6915(13)00158-0 [pii]
AID - 10.1016/j.fct.2013.02.049 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2013 Jun;56:398-405. doi: 10.1016/j.fct.2013.02.049. Epub 2013 
      Mar 7.