PMID- 23499774 OWN - NLM STAT- MEDLINE DCOM- 20140403 LR - 20130530 IS - 1567-7257 (Electronic) IS - 1567-1348 (Linking) VI - 16 DP - 2013 Jun TI - Association of HLA-G 3'UTR polymorphisms with response to malaria infection: a first insight. PG - 263-9 LID - S1567-1348(13)00071-3 [pii] LID - 10.1016/j.meegid.2013.02.021 [doi] AB - Malaria represents one of the most important causes of mortality and morbidity in Africa. Variability in clinical presentation is partly due to host genetic polymorphisms. Among them, human leukocyte antigen (HLA) class I and class II alleles may be responsible for malaria susceptibility; however less is known about the possible role of non classical HLA molecules. Among them, HLA-G is a tolerogenic molecule with immunomodulatory properties, which differs from classical HLA class I molecules by its lower genetic diversity, tissue expression and function. Although primarily associated with maternal-fetal tolerance, HLA-G is now known to be involved in a wide range of physiopathological conditions, such as tumor, autoimmunity, transplantation, inflammation and viral infection by suppressing the function of various immune cells. In this work, we present the first evidence of an association between HLA-G 3'UTR polymorphisms and malaria infection. More precisely, we showed that HLA-G polymorphisms are associated with asymptomatic infection through two parasitological phenotypes, the intensity of Plasmodium falciparum infection and the mean level of parasite density. The allele+3187G and its haplotype (UTR-1, 14bp-Del/3001C/3003T/3010G/3035C/3052C/3142C/3187G/3196C) was associated with lower level of infection under a dominant model, and the haplotype UTR-3 (Del/3001C/3003T/3010C/3035C/3152C/3142G/3187A/3196C) was associated with high levels of infection under a recessive model. In conclusion, although further investigations are on the way to better address the possible involvement of the HLA-G molecule in the control of P. falciparum infection, this work presents the first evidence of an association between HLA-G polymorphisms and malaria infection. Further investigations are on the way to take into account the particularities of African populations. CI - Copyright (c) 2013 Elsevier B.V. All rights reserved. FAU - Garcia, Andre AU - Garcia A AD - Institut de Recherche pour le Developpement, UMR 216, Mere et enfant face aux infections tropicales, Universite Paris Descartes, 4, avenue de l'Observatoire, 75006 Paris, France. Andre.Garcia@ird.fr FAU - Milet, Jacqueline AU - Milet J FAU - Courtin, David AU - Courtin D FAU - Sabbagh, Audrey AU - Sabbagh A FAU - Massaro, Juliana D AU - Massaro JD FAU - Castelli, Erick C AU - Castelli EC FAU - Migot-Nabias, Florence AU - Migot-Nabias F FAU - Favier, Benoit AU - Favier B FAU - Rouas-Freiss, Nathalie AU - Rouas-Freiss N FAU - Donadi, Eduardo A AU - Donadi EA FAU - Moreau, Philippe AU - Moreau P LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20130314 PL - Netherlands TA - Infect Genet Evol JT - Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases JID - 101084138 RN - 0 (3' Untranslated Regions) RN - 0 (HLA-G Antigens) SB - IM MH - *3' Untranslated Regions MH - Adolescent MH - Child MH - Child, Preschool MH - Female MH - Genetic Association Studies MH - Genetic Predisposition to Disease MH - HLA-G Antigens/*genetics/immunology MH - Haplotypes MH - Humans MH - Malaria, Falciparum/*genetics/immunology MH - Male MH - Polymorphism, Single Nucleotide EDAT- 2013/03/19 06:00 MHDA- 2014/04/04 06:00 CRDT- 2013/03/19 06:00 PHST- 2012/10/04 00:00 [received] PHST- 2013/02/21 00:00 [revised] PHST- 2013/02/22 00:00 [accepted] PHST- 2013/03/19 06:00 [entrez] PHST- 2013/03/19 06:00 [pubmed] PHST- 2014/04/04 06:00 [medline] AID - S1567-1348(13)00071-3 [pii] AID - 10.1016/j.meegid.2013.02.021 [doi] PST - ppublish SO - Infect Genet Evol. 2013 Jun;16:263-9. doi: 10.1016/j.meegid.2013.02.021. Epub 2013 Mar 14.