PMID- 23500246 OWN - NLM STAT- MEDLINE DCOM- 20130530 LR - 20191210 IS - 1558-3597 (Electronic) IS - 0735-1097 (Linking) VI - 61 IP - 14 DP - 2013 Apr 9 TI - Cardiac magnetic resonance imaging in the evaluation of the late effects of anthracyclines among long-term survivors of childhood cancer. PG - 1539-47 LID - S0735-1097(13)00380-X [pii] LID - 10.1016/j.jacc.2013.01.019 [doi] AB - OBJECTIVES: This study sought to examine the left ventricular (LV) and right ventricular (RV) function and signs of focal fibrosis among long-term survivors of childhood cancer with the use of cardiac magnetic resonance (CMR) imaging. BACKGROUND: Increased myocardial fibrosis has been detected in the endomyocardial biopsies of survivors. CMR has established its role in the assessment of both cardiac function and structure, and focal fibrosis of the myocardium is detectable with late gadolinium enhancement (LGE). METHODS: Sixty-two anthracycline-exposed long-term survivors of childhood cancer were studied at a mean age of 14.6 years. The LV and RV ejection fractions (EFs) and volumes were measured, and LGE was assessed using CMR. RESULTS: An abnormal LV function (EF <45%) was detected in 18% (11 of 62) of the survivors, and an abnormal RV function was detected in 27% (17 of 62) of the survivors. Subnormal (45%