PMID- 23506224
OWN - NLM
STAT- MEDLINE
DCOM- 20131017
LR  - 20220321
IS  - 1525-1594 (Electronic)
IS  - 0160-564X (Linking)
VI  - 37
IP  - 5
DP  - 2013 May
TI  - Efficacy of carbon dioxide insufflation for cerebral and cardiac protection 
      during open heart surgery: a systematic review and meta-analysis.
PG  - 439-46
LID - 10.1111/aor.12042 [doi]
AB  - In spite of widespread application around the world, there has been controversy 
      on the cerebral and cardiac protection efficacy of carbon dioxide insufflation 
      (CDI) during open heart surgery. To make a comprehensive evaluation, we screened 
      all relevant published randomized controlled trials to perform the first 
      systematic review and meta-analysis for CDI during open heart surgery. We 
      searched PubMed, EMBASE, the Cochrane Controlled Clinical Trial register, WANFAN, 
      CQVIP, and CNKI database for published articles. Randomized controlled trials 
      were included when the research provided data of neurological complications 
      postoperatively, creatinine kinase, MB isoenzyme (CK-MB) on the first 
      postoperative day, or all-cause mortality. We chose a fixed-effects model when 
      the trials showed low heterogeneity, otherwise a random effects model was used. 
      The quality of studies was assessed by modified Jadad scale. Four studies were 
      included in this meta-analysis. The overall pooled relative risk (RR) for 
      neurological complications was 1.59, 95% confidence interval (CI) = [0.57, 4.46], 
      and the z-score for overall effect was 0.89 (P = 0.37). The standardized mean 
      difference of the CK-MB between groups was 1.15, 95% CI = [-1.27, 3.56], and the 
      z-score for overall effect was 0.93 (P = 0.35). The overall pooled RR for 
      all-cause mortality was 0.5, 95% CI = [0.16, 1.64], and the z-score for overall 
      effect was 1.14 (P = 0.25). There was no significant difference between groups. 
      Because of the insufficiency of powerful evidences, the cerebral and cardiac 
      protection efficacy of CDI during open heart surgery needs to be further verified 
      by more high-quality trials.
CI  - (c) 2013, Copyright the Authors. Artificial Organs (c) 2013, International Center for 
      Artificial Organs and Transplantation and Wiley Periodicals, Inc.
FAU - Sun, Yanhua
AU  - Sun Y
AD  - Department of Cardiopulmonary Bypass, State Key Laboratory of Cardiovascular 
      Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese 
      Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
FAU - Ji, Bingyang
AU  - Ji B
FAU - Zhu, Xian
AU  - Zhu X
FAU - Zheng, Zhe
AU  - Zheng Z
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20130319
PL  - United States
TA  - Artif Organs
JT  - Artificial organs
JID - 7802778
RN  - 142M471B3J (Carbon Dioxide)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Carbon Dioxide/*administration & dosage/adverse effects
MH  - Cardiac Surgical Procedures/*adverse effects/mortality
MH  - Cerebrovascular Disorders/etiology/mortality/*prevention & control
MH  - Evidence-Based Medicine
MH  - Heart Diseases/etiology/mortality/*prevention & control
MH  - Humans
MH  - *Insufflation/adverse effects/mortality
MH  - Middle Aged
MH  - Risk Assessment
MH  - Risk Factors
MH  - Treatment Outcome
EDAT- 2013/03/20 06:00
MHDA- 2013/10/18 06:00
CRDT- 2013/03/20 06:00
PHST- 2013/03/20 06:00 [entrez]
PHST- 2013/03/20 06:00 [pubmed]
PHST- 2013/10/18 06:00 [medline]
AID - 10.1111/aor.12042 [doi]
PST - ppublish
SO  - Artif Organs. 2013 May;37(5):439-46. doi: 10.1111/aor.12042. Epub 2013 Mar 19.