PMID- 23506995
OWN - NLM
STAT- MEDLINE
DCOM- 20131024
LR  - 20131121
IS  - 1872-7573 (Electronic)
IS  - 0378-8741 (Linking)
VI  - 147
IP  - 1
DP  - 2013 May 2
TI  - Essential oil of Perilla frutescens-induced change in hippocampal expression of 
      brain-derived neurotrophic factor in chronic unpredictable mild stress in mice.
PG  - 245-53
LID - S0378-8741(13)00158-X [pii]
LID - 10.1016/j.jep.2013.03.015 [doi]
AB  - ETHNOPHARMACOLOGICAL RELEVANCE: Perilla frutescens (Perilla leaf), a traditional 
      Chinese medicinal herb, has been used for centuries to treat various conditions 
      including depression. A previous study of the authors demonstrated that essential 
      oil of Perilla frutescens (EOPF) attenuated the depressive-like behavior in mice. 
      AIM OF THE STUDY: This study was undertaken to explore the dynamic change of 
      behaviors and brain-derived neurotrophic factor (BDNF) expression induced by 
      chronic unpredictable mild stress (CUMS), and improved by EOPF. MATERIALS AND 
      METHODS: Four separate CUMS experimental groups (1-week, 2-week, 3-week and 
      4-week treatment) were treated with EOPF (3 mg/kg and 6 mg/kg, p.o.) or 
      fluoxetine (20 mg/kg, p.o.), followed by sucrose preference, locomotor activity, 
      immobility and hippocampal BDNF measurement. RESULTS: EOPF, as well as 
      fluoxetine, restored the CUMS-induced decreased sucrose preference and increased 
      immobility time, without affecting body weight gain and locomotor activity. 
      Furthermore, CUMS (3 or 4-week) produced a reduction in both BDNF mRNA and 
      protein expression in the hippocampus, which were ameliorated by EOPF (4-week) 
      and fluoxetine (3 or 4-week) treatment. CONCLUSION: These results presented here 
      show that BDNF is expressed depending on length of CUMS procedure and EOPF 
      administration. And this study might contribute to the underlying reason for the 
      slow onset of antidepressant activity in clinic.
CI  - Copyright (c) 2013 Elsevier Ireland Ltd. All rights reserved.
FAU - Yi, Li-Tao
AU  - Yi LT
AD  - Department of Chemical and Pharmaceutical Engineering, College of Chemical 
      Engineering, Huaqiao University, Xiamen 361021, Fujian province, PR China. 
      litao.yi@yahoo.com
FAU - Li, Jing
AU  - Li J
FAU - Geng, Di
AU  - Geng D
FAU - Liu, Bin-Bin
AU  - Liu BB
FAU - Fu, Ying
AU  - Fu Y
FAU - Tu, Jia-Qi
AU  - Tu JQ
FAU - Liu, Yuan
AU  - Liu Y
FAU - Weng, Lian-Jin
AU  - Weng LJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130315
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Oils, Volatile)
RN  - 0 (Plant Oils)
RN  - 0 (RNA, Messenger)
RN  - 01K63SUP8D (Fluoxetine)
RN  - 0RBV727H71 (alpha-Linolenic Acid)
RN  - 57-50-1 (Sucrose)
RN  - 68132-21-8 (perilla seed oil)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/isolation & purification/*pharmacology
MH  - Behavior, Animal/drug effects
MH  - Body Weight/drug effects
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Chronic Disease
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Down-Regulation
MH  - Drugs, Chinese Herbal/isolation & purification/*pharmacology
MH  - Fluoxetine/pharmacology
MH  - Food Preferences/drug effects
MH  - Hippocampus/*drug effects/metabolism
MH  - Male
MH  - Medicine, Chinese Traditional
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Motor Activity/drug effects
MH  - Oils, Volatile/isolation & purification/*pharmacology
MH  - *Perilla frutescens/chemistry
MH  - Phytotherapy
MH  - Plant Leaves
MH  - Plant Oils/isolation & purification/pharmacology
MH  - Plants, Medicinal
MH  - RNA, Messenger/metabolism
MH  - Stress, Psychological/*drug therapy/genetics/metabolism/psychology
MH  - Sucrose
MH  - Time Factors
MH  - alpha-Linolenic Acid/isolation & purification/*pharmacology
EDAT- 2013/03/20 06:00
MHDA- 2013/10/25 06:00
CRDT- 2013/03/20 06:00
PHST- 2012/10/18 00:00 [received]
PHST- 2013/01/17 00:00 [revised]
PHST- 2013/03/07 00:00 [accepted]
PHST- 2013/03/20 06:00 [entrez]
PHST- 2013/03/20 06:00 [pubmed]
PHST- 2013/10/25 06:00 [medline]
AID - S0378-8741(13)00158-X [pii]
AID - 10.1016/j.jep.2013.03.015 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2013 May 2;147(1):245-53. doi: 10.1016/j.jep.2013.03.015. Epub 
      2013 Mar 15.