PMID- 23507383
OWN - NLM
STAT- MEDLINE
DCOM- 20140108
LR  - 20130506
IS  - 1095-9572 (Electronic)
IS  - 1053-8119 (Linking)
VI  - 76
DP  - 2013 Aug 1
TI  - Dynamic causal modelling of effective connectivity during perspective taking in a 
      communicative task.
PG  - 116-24
LID - S1053-8119(13)00227-9 [pii]
LID - 10.1016/j.neuroimage.2013.02.072 [doi]
AB  - Previous studies have shown that taking into account another person's perspective 
      to guide decisions is more difficult when their perspective is incongruent from 
      one's own compared to when it is congruent. Here we used dynamic causal modelling 
      (DCM) for functional magnetic resonance imaging (fMRI) to investigate effective 
      connectivity between prefrontal and posterior brain regions in a task that 
      requires participants to take into account another person's perspective in order 
      to guide the selection of an action. Using a new procedure to score model 
      evidence without computationally costly estimation, we conducted an exhaustive 
      search for the best of all possible models. The results elucidate how the 
      activity in the areas from our previously reported analysis (Dumontheil et al., 
      2010) are causally linked and how the connections are modulated by both the 
      social as well as executive task demands of the task. We find that the social 
      demands modulate the backward connections from the medial prefrontal cortex 
      (MPFC) more strongly than the forward connections from the superior occipital 
      gyrus (SOG) and the medial temporal gyrus (MTG) to the MPFC. This was also the 
      case for the backward connection from the MTG to the SOG. Conversely, the 
      executive task demands modulated the forward connections of the SOG and the MTG 
      to the MPFC more strongly than the backward connections. We interpret the results 
      in terms of hierarchical predictive coding.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Hillebrandt, Hauke
AU  - Hillebrandt H
AD  - Institute of Cognitive Neuroscience, University College London, UK. 
      hauke.hillebrandt@gmail.com
FAU - Dumontheil, Iroise
AU  - Dumontheil I
FAU - Blakemore, Sarah-Jayne
AU  - Blakemore SJ
FAU - Roiser, Jonathan P
AU  - Roiser JP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130316
PL  - United States
TA  - Neuroimage
JT  - NeuroImage
JID - 9215515
SB  - IM
MH  - Adult
MH  - Bayes Theorem
MH  - Brain/*physiology
MH  - *Brain Mapping
MH  - Female
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - *Models, Neurological
MH  - Neural Pathways/*physiology
MH  - Theory of Mind/*physiology
MH  - Young Adult
EDAT- 2013/03/20 06:00
MHDA- 2014/01/09 06:00
CRDT- 2013/03/20 06:00
PHST- 2012/10/09 00:00 [received]
PHST- 2013/02/09 00:00 [revised]
PHST- 2013/02/26 00:00 [accepted]
PHST- 2013/03/20 06:00 [entrez]
PHST- 2013/03/20 06:00 [pubmed]
PHST- 2014/01/09 06:00 [medline]
AID - S1053-8119(13)00227-9 [pii]
AID - 10.1016/j.neuroimage.2013.02.072 [doi]
PST - ppublish
SO  - Neuroimage. 2013 Aug 1;76:116-24. doi: 10.1016/j.neuroimage.2013.02.072. Epub 
      2013 Mar 16.