PMID- 23507630
OWN - NLM
STAT- MEDLINE
DCOM- 20141024
LR  - 20240404
IS  - 1878-7533 (Electronic)
IS  - 1550-7289 (Linking)
VI  - 10
IP  - 1
DP  - 2014 Jan-Feb
TI  - The effect of selective gut stimulation on glucose metabolism after gastric 
      bypass in the Zucker diabetic fatty rat model.
PG  - 29-35
LID - S1550-7289(13)00042-7 [pii]
LID - 10.1016/j.soard.2013.01.021 [doi]
AB  - BACKGROUND: Potential mechanisms underlying the antidiabetic effects of Roux-en-Y 
      gastric bypass (RYGB) include altered nutrient exposure in the gut. The aim of 
      this study was to evaluate the effects of selective gut stimulation on glucose 
      metabolism in an obese diabetic rat model. METHODS: Sixteen male Zucker diabetic 
      fatty rats were randomly assigned to 1 of 2 groups: RYGB with gastrostomy tube 
      (GT) insertion into the excluded stomach or a control group with GT insertion 
      into the stomach. An insulin tolerance test (ITT), oral glucose tolerance test 
      (OGTT), and mixed meal tolerance test (MMTT) were performed before and 14-28 days 
      after surgery. A glucose tolerance test via GT (GTT-GT) and MMTT via GT were 
      performed postoperatively. RESULTS: Postoperatively, the RYGB group had 
      significant decreases in weight and food intake. Both the ITT and OGTT tests 
      revealed significantly improved glucose tolerance after RYGB. The GTT-GT showed a 
      reversal of the improved glucose tolerance in the RYGB group. In response to meal 
      stimulation, postoperatively, the RYGB group increased glucagon-like peptide 1 
      (GLP-1) secretion via the oral route and peptide YY secretion by both oral and GT 
      routes. CONCLUSION: When foregut exposure to nutrients was reversed after RYGB, 
      the improvement in glucose metabolism was abrogated. This model can be extended 
      to identify the role of gut in glucose homeostasis in type 2 diabetes.
CI  - Copyright (c) 2014 American Society for Bariatric Surgery. Published by Elsevier 
      Inc. All rights reserved.
FAU - Shimizu, Hideharu
AU  - Shimizu H
AD  - Bariatric and Metabolic Institute, Cleveland Clinic, Cleveland, Ohio.
FAU - Eldar, Shai
AU  - Eldar S
AD  - Bariatric and Metabolic Institute, Cleveland Clinic, Cleveland, Ohio.
FAU - Heneghan, Helen M
AU  - Heneghan HM
AD  - Bariatric and Metabolic Institute, Cleveland Clinic, Cleveland, Ohio.
FAU - Schauer, Philip R
AU  - Schauer PR
AD  - Bariatric and Metabolic Institute, Cleveland Clinic, Cleveland, Ohio.
FAU - Kirwan, John P
AU  - Kirwan JP
AD  - Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, 
      Cleveland, Ohio; Metabolic Translational Research Center, Endocrine and 
      Metabolism Institute, Cleveland Clinic, Cleveland, Ohio.
FAU - Brethauer, Stacy A
AU  - Brethauer SA
AD  - Bariatric and Metabolic Institute, Cleveland Clinic, Cleveland, Ohio. Electronic 
      address: brethas@ccf.org.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130211
PL  - United States
TA  - Surg Obes Relat Dis
JT  - Surgery for obesity and related diseases : official journal of the American 
      Society for Bariatric Surgery
JID - 101233161
RN  - 0 (Blood Glucose)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
RN  - 106388-42-5 (Peptide YY)
RN  - 89750-14-1 (Glucagon-Like Peptide 1)
SB  - IM
MH  - Animals
MH  - Blood Glucose/*metabolism
MH  - Body Weight/physiology
MH  - Diabetes Mellitus, Experimental/metabolism
MH  - Diabetes Mellitus, Type 2/metabolism
MH  - Eating/physiology
MH  - Fasting/metabolism
MH  - *Gastric Bypass
MH  - Glucagon-Like Peptide 1/metabolism
MH  - Glucose Tolerance Test
MH  - Homeostasis/physiology
MH  - Hypoglycemic Agents/pharmacology
MH  - Insulin/pharmacology
MH  - Male
MH  - Peptide YY/metabolism
MH  - Postoperative Period
MH  - Random Allocation
MH  - Rats, Zucker
OTO - NOTNLM
OT  - Gastrointestinal hormones
OT  - Insulin resistance
OT  - Obesity
OT  - Roux-en-Y gastric bypass
OT  - Type 2 diabetes
EDAT- 2013/03/20 06:00
MHDA- 2014/10/25 06:00
CRDT- 2013/03/20 06:00
PHST- 2012/07/29 00:00 [received]
PHST- 2013/01/02 00:00 [revised]
PHST- 2013/01/03 00:00 [accepted]
PHST- 2013/03/20 06:00 [entrez]
PHST- 2013/03/20 06:00 [pubmed]
PHST- 2014/10/25 06:00 [medline]
AID - S1550-7289(13)00042-7 [pii]
AID - 10.1016/j.soard.2013.01.021 [doi]
PST - ppublish
SO  - Surg Obes Relat Dis. 2014 Jan-Feb;10(1):29-35. doi: 10.1016/j.soard.2013.01.021. 
      Epub 2013 Feb 11.