PMID- 23508474
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130320
LR  - 20211021
IS  - 1662-5145 (Print)
IS  - 1662-5145 (Electronic)
IS  - 1662-5145 (Linking)
VI  - 7
DP  - 2013
TI  - Persistent deficits in hippocampal synaptic plasticity accompany losses of 
      hippocampus-dependent memory in a rodent model of psychosis.
PG  - 12
LID - 10.3389/fnint.2013.00012 [doi]
LID - 12
AB  - Irreversible N-methyl-D-aspartate receptor (NMDAR) antagonism is known to provoke 
      symptoms of psychosis and schizophrenia in healthy humans. NMDAR hypofunction is 
      believed to play a central role in the pathophysiology of both disorders and in 
      an animal model of psychosis, that is based on irreversible antagonism of NMDARs, 
      pronounced deficits in hippocampal synaptic plasticity have been reported shortly 
      after antagonist treatment. Here, we examined the long-term consequences for 
      long-term potentiation (LTP) of a single acute treatment with an irreversible 
      antagonist and investigated whether deficits are associated with memory 
      impairments. The ability to express LTP at the perforant pathway - dentate gyrus 
      synapse, as well as object recognition memory was assessed 1, 2, 3, and 4 weeks 
      after a single treatment of the antagonist, MK801. Here, LTP in freely behaving 
      rats was significantly impaired at all time-points compared to control LTP before 
      treatment. Object recognition memory was also significantly poorer in 
      MK801-treated compared to vehicle-treated animals for several weeks after 
      treatment. Histological analysis revealed no changes in brain tissue. Taken 
      together, these data support that acute treatment with an irreversible 
      NMDAR-antagonist persistently impairs hippocampal functioning on behavioral, as 
      well as synaptic levels. The long-term deficits in synaptic plasticity may 
      underlie the cognitive impairments that are associated with 
      schizophrenia-spectrum disorders.
FAU - Wiescholleck, Valentina
AU  - Wiescholleck V
AD  - Department of Neurophysiology, Medical Faculty, Ruhr University Bochum Bochum, 
      Germany ; International Graduate School of Neuroscience, Ruhr University Bochum 
      Bochum, Germany.
FAU - Manahan-Vaughan, Denise
AU  - Manahan-Vaughan D
LA  - eng
PT  - Journal Article
DEP - 20130315
PL  - Switzerland
TA  - Front Integr Neurosci
JT  - Frontiers in integrative neuroscience
JID - 101477950
PMC - PMC3597980
OTO - NOTNLM
OT  - MK801
OT  - dentate gyrus
OT  - in vivo
OT  - long-term potentiation
OT  - schizophrenia
EDAT- 2013/03/20 06:00
MHDA- 2013/03/20 06:01
PMCR- 2013/01/01
CRDT- 2013/03/20 06:00
PHST- 2012/12/21 00:00 [received]
PHST- 2013/02/22 00:00 [accepted]
PHST- 2013/03/20 06:00 [entrez]
PHST- 2013/03/20 06:00 [pubmed]
PHST- 2013/03/20 06:01 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - 10.3389/fnint.2013.00012 [doi]
PST - epublish
SO  - Front Integr Neurosci. 2013 Mar 15;7:12. doi: 10.3389/fnint.2013.00012. 
      eCollection 2013.