PMID- 23508562
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130320
LR  - 20211021
IS  - 2228-5806 (Print)
IS  - 2228-5814 (Electronic)
IS  - 2228-5806 (Linking)
VI  - 14
IP  - 3
DP  - 2012 Fall
TI  - Zingiber Officinale Alters 3,4-methylenedioxymethamphetamine-Induced 
      Neurotoxicity in Rat Brain.
PG  - 177-84
AB  - OBJECTIVE: The spice Zingiber officinale or ginger possesses antioxidant activity 
      and neuroprotective effects. The effects of this traditional herbal medicine on 
      3,4-methylenedioxymethamphetamine (MDMA) induced neurotoxicity have not yet been 
      studied. The present study considers the effects of Zingiber officinale on 
      MDMA-induced spatial memory impairment and apoptosis in the hippocampus of male 
      rats. MATERIALS AND METHODS: In this experimental study, 21 adult male Sprague 
      Dawley rats (200-250 g) were classified into three groups (control, MDMA, and 
      MDMA plus ginger). The groups were intraperitoneally administered 10 mg/kg MDMA, 
      10 mg/kg MDMA plus 100 mg/kg ginger extract, or 1 cc/kg normal saline as the 
      control solution for one week (n=7 per group). Learning memory was assessed by 
      Morris water maze (MWM) after the last administration. Finally, the brains were 
      removed to study the cell number in the cornu ammonis (CA1) hippocampus by light 
      microscope, Bcl-2 by immunoblotting, and Bax expression by reverse transcription 
      polymerase chain reaction (RT-PCR). Data was analyzed using SPSS 16 software and 
      a one-way ANOVA test. RESULTS: Escape latency and traveled distances decreased 
      significantly in the MDMA plus ginger group relative to the MDMA group (p<0.001). 
      Cell number increased in the MDMA plus ginger group in comparison to the MDMA 
      group. Down-regulation of Bcl-2 and up-regulation of Bax were observed in the 
      MDMA plus ginger group in comparison to the MDMA group (p<0.05). CONCLUSION: Our 
      findings suggest that ginger consumption may lead to an improvement of 
      MDMA-induced neurotoxicity.
FAU - Mehdizadeh, Mehdi
AU  - Mehdizadeh M
AD  - 1. Research Institute for Islamic and Complementary Medicine (RICM), Tehran 
      University of Medical Sciences, Tehran, Iran ; 2. Department of Anatomy, Faculty 
      of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Dabaghian, Fataneh
AU  - Dabaghian F
FAU - Nejhadi, Akram
AU  - Nejhadi A
FAU - Fallah-Huseini, Hassan
AU  - Fallah-Huseini H
FAU - Choopani, Samira
AU  - Choopani S
FAU - Shekarriz, Nima
AU  - Shekarriz N
FAU - Molavi, Nima
AU  - Molavi N
FAU - Basirat, Arghavan
AU  - Basirat A
FAU - Mohammadzadeh Kazorgah, Farzaneh
AU  - Mohammadzadeh Kazorgah F
FAU - Samzadeh-Kermani, Alireza
AU  - Samzadeh-Kermani A
FAU - Soleimani Asl, Sara
AU  - Soleimani Asl S
LA  - eng
PT  - Journal Article
DEP - 20121212
PL  - Iran
TA  - Cell J
JT  - Cell journal
JID - 101566618
PMC - PMC3584433
OTO - NOTNLM
OT  - Apoptosis
OT  - Bcl-2 Family
OT  - Ginger
OT  - Hippocampus
OT  - MDMA
OT  - Spatial Memory
EDAT- 2013/03/20 06:00
MHDA- 2013/03/20 06:01
PMCR- 2012/09/01
CRDT- 2013/03/20 06:00
PHST- 2011/10/25 00:00 [received]
PHST- 2012/05/16 00:00 [accepted]
PHST- 2013/03/20 06:00 [entrez]
PHST- 2013/03/20 06:00 [pubmed]
PHST- 2013/03/20 06:01 [medline]
PHST- 2012/09/01 00:00 [pmc-release]
PST - ppublish
SO  - Cell J. 2012 Fall;14(3):177-84. Epub 2012 Dec 12.