PMID- 23508652
OWN - NLM
STAT- MEDLINE
DCOM- 20140409
LR  - 20151119
IS  - 1477-0970 (Electronic)
IS  - 1352-4585 (Linking)
VI  - 19
IP  - 9
DP  - 2013 Aug
TI  - Clinically silent PML and prolonged immune reconstitution inflammatory syndrome 
      in a patient with multiple sclerosis treated with natalizumab.
PG  - 1226-9
LID - 10.1177/1352458513481010 [doi]
AB  - We report the case of a woman with natalizumab-treated multiple sclerosis (MS) 
      and clinically silent progressive multifocal leukoencephalopathy (PML) with an 
      unusually long preclinical phase, followed by acute symptoms due to development 
      of immune reconstitution inflammatory syndrome (IRIS). Furthermore, the course of 
      the IRIS was prolonged and continued to progress even five months after 
      natalizumab treatment was ceased. This case shows that PML and IRIS can have a 
      considerably variable course in natalizumab-treated MS patients and underlines 
      the need for PML screening in JC virus antibody-positive patients in order to 
      detect clinically silent cases.
FAU - Blinkenberg, Morten
AU  - Blinkenberg M
AD  - Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University 
      Hospital, Rigshospitalet, Denmark. blink@dadlnet.dk
FAU - Sellebjerg, Finn
AU  - Sellebjerg F
FAU - Leffers, Anne-Mette
AU  - Leffers AM
FAU - Madsen, Camilla Gobel
AU  - Madsen CG
FAU - Sorensen, Per Soelberg
AU  - Sorensen PS
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130318
PL  - England
TA  - Mult Scler
JT  - Multiple sclerosis (Houndmills, Basingstoke, England)
JID - 9509185
RN  - 0 (Antibodies, Monoclonal, Humanized)
RN  - 0 (Natalizumab)
SB  - IM
MH  - Adenocarcinoma/complications
MH  - Antibodies, Monoclonal, Humanized/*therapeutic use
MH  - Breast Neoplasms/complications
MH  - Cerebellum/pathology
MH  - Female
MH  - Humans
MH  - Immune Reconstitution Inflammatory 
      Syndrome/*complications/pathology/physiopathology
MH  - JC Virus
MH  - Leukoencephalopathy, Progressive 
      Multifocal/*complications/pathology/physiopathology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis, Relapsing-Remitting/*complications/drug 
      therapy/physiopathology
MH  - Natalizumab
OTO - NOTNLM
OT  - IRIS
OT  - PML
OT  - multiple sclerosis
OT  - natalizumab
EDAT- 2013/03/20 06:00
MHDA- 2014/04/10 06:00
CRDT- 2013/03/20 06:00
PHST- 2013/03/20 06:00 [entrez]
PHST- 2013/03/20 06:00 [pubmed]
PHST- 2014/04/10 06:00 [medline]
AID - 1352458513481010 [pii]
AID - 10.1177/1352458513481010 [doi]
PST - ppublish
SO  - Mult Scler. 2013 Aug;19(9):1226-9. doi: 10.1177/1352458513481010. Epub 2013 Mar 
      18.