PMID- 23509631
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130320
LR  - 20211021
IS  - 2090-3448 (Print)
IS  - 2090-3456 (Electronic)
VI  - 2013
DP  - 2013
TI  - Value and limits of routine histology alone or combined with glutamine synthetase 
      immunostaining in the diagnosis of hepatocellular adenoma subtypes on surgical 
      specimens.
PG  - 417323
LID - 10.1155/2013/417323 [doi]
LID - 417323
AB  - Immunohistochemistry is a valid method to classify hepatocellular adenoma (HCA). 
      The aim was to test the performance of routine histology combined to glutamine 
      synthetase (GS) staining to identify the 2 major HCA subtypes: HNF1 alpha inactivated 
      (H-HCA) and inflammatory HCA (IHCA). 114 surgical cases, previously classified by 
      immunohistochemistry, were analysed. Group A comprised 45 H-HCAs, 44 IHCAs, and 9 
      beta -catenin-activated IHCAs (b-IHCA), and group B, 16 b-HCA and unclassified HCA 
      (UHCA). Steatosis was the hallmark of H-HCA. IHCA and b-IHCA were mainly 
      characterized by inflammation, thick arteries, and sinusoidal dilatation; b-IHCA 
      could not be differentiated from IHCA by routine histology. Group B was 
      identified by default. A control set (91 cases) was analyzed using routine and GS 
      stainings (without knowing immunohistochemical results). Among the 45 H-HCAs and 
      27 IHCAs, 40 and 24 were correctly classified, respectively. Among the 10 
      b-IHCAs, 4 were identified as such using additional GS. Eight of the 9 HCAs that 
      were neither H-HCA nor IHCA were correctly classified. Conclusion. Routine 
      histology allows to diagnose >85% of the 2 major HCA subtypes. GS is essential to 
      identify b-HCA. This study demonstrates that a "palliative" diagnostic approach 
      can be proposed, when the panel of specific antibodies is not available.
FAU - Bioulac-Sage, Paulette
AU  - Bioulac-Sage P
AD  - Service d'Anatomie Pathologique, Hopital Pellegrin, CHU Bordeaux, Place Amelie 
      Raba Leon, 33075 Bordeaux Cedex, France ; Inserm U1053 Universite Bordeaux 
      Segalen, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France.
FAU - Taouji, Said
AU  - Taouji S
FAU - Le Bail, Brigitte
AU  - Le Bail B
FAU - Possenti, Laurent
AU  - Possenti L
FAU - Balabaud, Charles
AU  - Balabaud C
LA  - eng
PT  - Journal Article
DEP - 20130219
PL  - United States
TA  - Int J Hepatol
JT  - International journal of hepatology
JID - 101564967
PMC - PMC3590632
EDAT- 2013/03/20 06:00
MHDA- 2013/03/20 06:01
PMCR- 2013/02/19
CRDT- 2013/03/20 06:00
PHST- 2012/10/03 00:00 [received]
PHST- 2012/12/23 00:00 [accepted]
PHST- 2013/03/20 06:00 [entrez]
PHST- 2013/03/20 06:00 [pubmed]
PHST- 2013/03/20 06:01 [medline]
PHST- 2013/02/19 00:00 [pmc-release]
AID - 10.1155/2013/417323 [doi]
PST - ppublish
SO  - Int J Hepatol. 2013;2013:417323. doi: 10.1155/2013/417323. Epub 2013 Feb 19.