PMID- 23510674
OWN - NLM
STAT- MEDLINE
DCOM- 20130628
LR  - 20130429
IS  - 1096-0341 (Electronic)
IS  - 0042-6822 (Linking)
VI  - 440
IP  - 2
DP  - 2013 Jun 5
TI  - Kaposi's-sarcoma-associated-herpesvirus-activated dendritic cells promote HIV-1 
      trans-infection and suppress CD4(+) T cell proliferation.
PG  - 150-9
LID - S0042-6822(13)00123-2 [pii]
LID - 10.1016/j.virol.2013.02.018 [doi]
AB  - Infection of Kaposi's sarcoma-associated herpesvirus (KSHV) is commonly occurred 
      in AIDS patients. KSHV and HIV-1 act cooperatively in regulating infection with 
      each other and in human carcinogenesis. Dendritic cells (DCs), as the pivotal 
      cells in host immunity, may be modulated by both viruses, for immunoevasion and 
      dissemination, therefore, the interaction between DCs and each virus has been a 
      prior focus for pathogenesis elucidation. Here, we assessed the potential effect 
      of KSHV on DC-HIV-1 interaction. We found that KSHV stimulation could promote 
      maturation of monocyte-derived DCs (MDDCs) and impaired the ability of MDDCs to 
      drive proliferation of resting CD4(+) T cells, demonstrating the 
      immunosuppression induced by KSHV. More importantly, KSHV-stimulated MDDCs could 
      capture more HIV-1 and efficiently transferred these infectious viruses to 
      Hut/CCR5 T cell line. Our results reveal the novel modulation of DC-mediated 
      HIV-1 dissemination by KSHV, and highlight the importance of studying DC-HIV-1 
      interaction to elucidate HIV/AIDS pathogenesis.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Liu, Wan
AU  - Liu W
AD  - Key Laboratory of Molecular Virology & Immunology, Institute Pasteur of Shanghai, 
      the Chinese Academy of Sciences, Shanghai, China.
FAU - Qin, Yan
AU  - Qin Y
FAU - Bai, Lei
AU  - Bai L
FAU - Lan, Ke
AU  - Lan K
FAU - Wang, Jian-Hua
AU  - Wang JH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130316
PL  - United States
TA  - Virology
JT  - Virology
JID - 0110674
SB  - IM
MH  - CD4-Positive T-Lymphocytes/immunology/*virology
MH  - *Cell Proliferation
MH  - Dendritic Cells/immunology/*virology
MH  - HIV-1/immunology/*pathogenicity
MH  - Herpesvirus 8, Human/immunology/*pathogenicity
MH  - *Host-Pathogen Interactions
MH  - Humans
MH  - *Immune Evasion
EDAT- 2013/03/21 06:00
MHDA- 2013/07/03 06:00
CRDT- 2013/03/21 06:00
PHST- 2012/10/26 00:00 [received]
PHST- 2013/02/05 00:00 [revised]
PHST- 2013/02/20 00:00 [accepted]
PHST- 2013/03/21 06:00 [entrez]
PHST- 2013/03/21 06:00 [pubmed]
PHST- 2013/07/03 06:00 [medline]
AID - S0042-6822(13)00123-2 [pii]
AID - 10.1016/j.virol.2013.02.018 [doi]
PST - ppublish
SO  - Virology. 2013 Jun 5;440(2):150-9. doi: 10.1016/j.virol.2013.02.018. Epub 2013 
      Mar 16.