PMID- 23510795
OWN - NLM
STAT- MEDLINE
DCOM- 20131025
LR  - 20130415
IS  - 1525-5069 (Electronic)
IS  - 1525-5050 (Linking)
VI  - 27
IP  - 2
DP  - 2013 May
TI  - Personality traits in juvenile myoclonic epilepsy: evidence of cortical 
      abnormalities from a surface morphometry study.
PG  - 385-92
LID - S1525-5050(13)00054-1 [pii]
LID - 10.1016/j.yebeh.2013.02.004 [doi]
AB  - Cluster B personality disorders (PD), characterized as emotional instability, 
      immaturity, lack of discipline, and rapid mood changes, have been observed among 
      patients with juvenile myoclonic epilepsy (JME) and have been associated with a 
      worse seizure outcome. Proper understanding of the neurobiology of PD associated 
      with JME could contribute to understanding the basis for earlier and more 
      effective interventions. In the present study, volumetric and geometric features 
      of cortical structure were assessed through an automated cortical surface 
      reconstruction method aiming to verify possible structural cortical alterations 
      among patients with JME. Twenty-two patients with JME with cluster B PD, 44 
      patients with JME without psychiatric disorders, and 23 healthy controls were 
      submitted to a psychiatric evaluation through SCID I and SCID II and to an MRI 
      scan. Significant cortical alterations in mesiofrontal and frontobasal regions, 
      as well as in other limbic and paralimbic regions, were observed mainly in 
      patients with JME with PD. The present study adds evidence to the hypothesis of 
      frontal and limbic involvement in the pathophysiology of cluster B PD in JME, 
      regions linked to mood and affective regulation, as well as to impulsivity and 
      social behavior. Moreover, a multidimensional pattern of frontal, limbic, and 
      paralimbic changes was observed through a method of structural analysis which 
      offers different and simultaneous geometric features, allowing the elaboration of 
      important pathophysiologic insights about cluster B PD in JME.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - de Araujo Filho, Gerardo Maria
AU  - de Araujo Filho GM
AD  - Laboratorio Interdisciplinar de Neurociencias Clinicas (LiNC), Department of 
      Psychiatry, Universidade Federal de Sao Paulo/UNIFESP, Sao Paulo, Brazil. 
      filho.gerardo@gmail.com
FAU - de Araujo, Thabata Bueno
AU  - de Araujo TB
FAU - Sato, Joao Ricardo
AU  - Sato JR
FAU - Silva, Ivaldo da
AU  - Silva Id
FAU - Lin, Katia
AU  - Lin K
FAU - Junior, Henrique Carrete
AU  - Junior HC
FAU - Yacubian, Elza Marcia T
AU  - Yacubian EM
FAU - Jackowski, Andrea Parolin
AU  - Jackowski AP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130317
PL  - United States
TA  - Epilepsy Behav
JT  - Epilepsy & behavior : E&B
JID - 100892858
SB  - IM
MH  - Adult
MH  - Brain Mapping
MH  - Cerebral Cortex/*pathology
MH  - Electroencephalography
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Myoclonic Epilepsy, Juvenile/*complications/*pathology
MH  - Personality Disorders/*complications
MH  - Psychiatric Status Rating Scales
MH  - Young Adult
EDAT- 2013/03/21 06:00
MHDA- 2013/10/26 06:00
CRDT- 2013/03/21 06:00
PHST- 2012/12/19 00:00 [received]
PHST- 2013/02/04 00:00 [revised]
PHST- 2013/02/05 00:00 [accepted]
PHST- 2013/03/21 06:00 [entrez]
PHST- 2013/03/21 06:00 [pubmed]
PHST- 2013/10/26 06:00 [medline]
AID - S1525-5050(13)00054-1 [pii]
AID - 10.1016/j.yebeh.2013.02.004 [doi]
PST - ppublish
SO  - Epilepsy Behav. 2013 May;27(2):385-92. doi: 10.1016/j.yebeh.2013.02.004. Epub 
      2013 Mar 17.