PMID- 23512513
OWN - NLM
STAT- MEDLINE
DCOM- 20140609
LR  - 20221207
IS  - 1758-1052 (Electronic)
IS  - 0956-4624 (Linking)
VI  - 24
IP  - 1
DP  - 2013 Jan
TI  - HLA-B*5701 genetic screening among HIV-1 infected patients in Hong Kong: is this 
      a practical approach in Han-Chinese?
PG  - 50-2
LID - 10.1258/ijsa.2012.012102 [doi]
AB  - Abacavir hypersensitivity is associated with the presence of human leukocyte 
      antigen (HLA)-allele B*5701. However, the cost and workload of routine HLA-B*5701 
      pretreatment screening is relatively heavy. This study aimed to determine the 
      prevalence of the HLA-B*5701 allele in the HIV-positive population under care in 
      Hong Kong. Blood samples from 1264 HIV-1 infected patients in Hong Kong were 
      collected between 2007 and 2011 for this study. HLA-B*5701 screening of the study 
      group was determined by in-house polymerase chain reaction (PCR) followed by 
      confirmation using the AlleleSEQR((R)) HLA-B PCR/Sequencing Kit (Celera Corporation 
      for Abbott, San Francisco, USA). HLA-B*5701 carriers were identified among 3% of 
      Caucasians, 1% of non-Chinese Asians and 0.5% of Han-Chinese in Hong Kong. Our 
      findings revealed that HLA-B*5701 pretreatment screening might not be necessary 
      for the local Han-Chinese population due to its low prevalence.
FAU - To, S W C
AU  - To SW
AD  - Department of Microbiology, Queen Mary Hospital, The University of Hong Kong.
FAU - Chen, J H K
AU  - Chen JH
FAU - Wong, K H
AU  - Wong KH
FAU - Chan, K C W
AU  - Chan KC
FAU - Tsang, O T Y
AU  - Tsang OT
FAU - Yam, W C
AU  - Yam WC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130506
PL  - England
TA  - Int J STD AIDS
JT  - International journal of STD & AIDS
JID - 9007917
RN  - 0 (Dideoxynucleosides)
RN  - 0 (Genetic Markers)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B*57:01 antigen)
RN  - 0 (Reverse Transcriptase Inhibitors)
RN  - WR2TIP26VS (abacavir)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Asian People/*genetics
MH  - Dideoxynucleosides/*therapeutic use
MH  - Drug Hypersensitivity/*genetics
MH  - Female
MH  - Genetic Markers
MH  - Genetic Testing/*methods
MH  - Genotype
MH  - HIV Infections/*drug therapy/immunology
MH  - HIV-1/genetics
MH  - HLA-B Antigens/blood/*genetics
MH  - Hong Kong
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Molecular Sequence Data
MH  - Polymerase Chain Reaction
MH  - Reverse Transcriptase Inhibitors/*adverse effects/therapeutic use
MH  - Young Adult
OTO - NOTNLM
OT  - HLA-B*5701
OT  - Han-Chinese
OT  - Hong Kong
OT  - abacavir hypersensitivity
EDAT- 2013/03/21 06:00
MHDA- 2014/06/10 06:00
CRDT- 2013/03/21 06:00
PHST- 2013/03/21 06:00 [entrez]
PHST- 2013/03/21 06:00 [pubmed]
PHST- 2014/06/10 06:00 [medline]
AID - ijsa.2012.012102 [pii]
AID - 10.1258/ijsa.2012.012102 [doi]
PST - ppublish
SO  - Int J STD AIDS. 2013 Jan;24(1):50-2. doi: 10.1258/ijsa.2012.012102. Epub 2013 May 
      6.