PMID- 23514230
OWN - NLM
STAT- MEDLINE
DCOM- 20130917
LR  - 20220331
IS  - 1557-7600 (Electronic)
IS  - 1096-620X (Linking)
VI  - 16
IP  - 4
DP  - 2013 Apr
TI  - Oral green tea catechins transiently lower plasma glucose concentrations in 
      female db/db mice.
PG  - 312-7
LID - 10.1089/jmf.2012.0205 [doi]
AB  - Polyphenols, including green tea catechins, are secondary plant compounds often 
      discussed in the context of health-promoting potential. Evidence for such effects 
      is mainly derived from epidemiological and cell culture studies. The aim of the 
      present study was to investigate antidiabetic, antiadipogenic, and 
      anti-inflammatory effects at nonpharmacological doses in an obese diabetic mouse 
      model that exerts early relevant clinical signs of non-insulin-dependent diabetes 
      mellitus. Female db/db mice received a flavonoid-poor diet either without 
      additive, with rosiglitazone (RSG, 0.02 g/kg diet), or with green tea extract 
      (low-dose green tea extract [LGTE] and high-dose green tea extract [HGTE], 0.1 
      and 1 g/kg diet). Food and water were freely available. The body weight was 
      monitored weekly. Blood was sampled (12-h fasted) from the tail vein on day 28 
      and analyzed for glucose, cholesterol, triacylglycerol, nonesterified fatty 
      acids, insulin, adiponectin, and soluble intercellular adhesion molecule-1 
      (sICAM-1). Blood glucose was also analyzed on day 14. Furthermore, sICAM-1 
      release was investigated in tumor necrosis factor alpha-stimulated EAhy926 cells. 
      After 14 days, fasting glycemia was improved by RSG or HGTE supplementation 
      compared to controls. However, at the end of the study (day 28), only RSG 
      exhibited glucose-lowering effects and induced plasma adiponectin concentrations, 
      paralleled by higher body weight gain and reduced periuterine fat pads compared 
      to controls. However, only GTE treatment reduced sICAM-1 release in vitro and in 
      vivo. Nonpharmacological HGTE supplementation in db/db mice caused (1) no 
      adiponectin-inducing or antiadipogenic effects, (2) reduced sICAM-1 release, 
      thereby potentially exerting anti-inflammatory effects in the progressive 
      diabetic state, and (3) a transient improvement in glycemia.
FAU - Wein, Silvia
AU  - Wein S
AD  - Institute of Animal Nutrition & Physiology, Christian Albrechts University of 
      Kiel, Kiel, Germany. wein@aninut.uni-kiel.de
FAU - Schrader, Eva
AU  - Schrader E
FAU - Rimbach, Gerald
AU  - Rimbach G
FAU - Wolffram, Siegfried
AU  - Wolffram S
LA  - eng
PT  - Journal Article
DEP - 20130320
PL  - United States
TA  - J Med Food
JT  - Journal of medicinal food
JID - 9812512
RN  - 0 (Adiponectin)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Blood Glucose)
RN  - 0 (Flavonoids)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Plant Extracts)
RN  - 0 (Thiazolidinediones)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 05V02F2KDG (Rosiglitazone)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - 8R1V1STN48 (Catechin)
SB  - IM
MH  - Adiponectin/blood
MH  - Adipose Tissue/drug effects/metabolism
MH  - Animals
MH  - Anti-Inflammatory Agents/pharmacology/therapeutic use
MH  - Blood Glucose/*metabolism
MH  - Camellia sinensis/*chemistry
MH  - Catechin/pharmacology/*therapeutic use
MH  - Diabetes Mellitus, Type 2/blood/*drug therapy/pathology
MH  - Dietary Supplements
MH  - Female
MH  - Flavonoids/administration & dosage
MH  - Hyperglycemia/drug therapy/metabolism
MH  - Hypoglycemic Agents/pharmacology/therapeutic use
MH  - Inflammation/metabolism/*prevention & control
MH  - Intercellular Adhesion Molecule-1/blood
MH  - Mice
MH  - Mice, Knockout
MH  - Mice, Obese
MH  - Obesity/blood/*drug therapy
MH  - *Phytotherapy
MH  - Plant Extracts/pharmacology/therapeutic use
MH  - Rosiglitazone
MH  - Thiazolidinediones/pharmacology/therapeutic use
MH  - Tumor Necrosis Factor-alpha
MH  - Weight Gain/drug effects
EDAT- 2013/03/22 06:00
MHDA- 2013/09/18 06:00
CRDT- 2013/03/22 06:00
PHST- 2013/03/22 06:00 [entrez]
PHST- 2013/03/22 06:00 [pubmed]
PHST- 2013/09/18 06:00 [medline]
AID - 10.1089/jmf.2012.0205 [doi]
PST - ppublish
SO  - J Med Food. 2013 Apr;16(4):312-7. doi: 10.1089/jmf.2012.0205. Epub 2013 Mar 20.