PMID- 23514232
OWN - NLM
STAT- MEDLINE
DCOM- 20130917
LR  - 20191210
IS  - 1557-7600 (Electronic)
IS  - 1096-620X (Linking)
VI  - 16
IP  - 4
DP  - 2013 Apr
TI  - Effect of kai xin san on learning and memory in a rat model of paradoxical sleep 
      deprivation.
PG  - 280-7
LID - 10.1089/jmf.2012.2486 [doi]
AB  - The present study aimed to evaluate the effect of kai xin san (KXS, at doses of 
      500, 250, and 125 mg/kg body weight per day), a well-known traditional Chinese 
      medicine, on learning and memory in paradoxical sleep deprivation (PSD)-induced 
      cognition deficit rats. Two behavior tests (the Open Field test and the Morris 
      water maze task) were used for testing the effects of KXS on a PSD-induced 
      learning and memory deficit model. Furthermore, its effect on the glutamic acid 
      (GLU) and gamma-amino-butyric acid (GABA) levels in the brain tissue, brain-derived 
      neurotrophic factor (BDNF), cyclic AMP response element binding protein (CREB), 
      and phosphorylated-CREB (p-CREB) expression in the hippocampus was also tested. 
      KXS exerted the greatest cognition against the 48 h PSD-induced cognitive deficit 
      and these effects may be mediated by decreasing the GLU and GABA levels and 
      increasing the levels of BDNF, CREB, and p-CREB. This study indicates that the 
      effect of KXS on learning and memory in a rat model of PSD could be associated 
      with the modulation of neurotransmitter levels and the expression of some genes 
      in the brain that contribute to memory functions.
FAU - Hu, Yuan
AU  - Hu Y
AD  - Department of Clinical Pharmacology, Chinese PLA General Hospital, Beijing, 
      China.
FAU - Liu, Ming
AU  - Liu M
FAU - Liu, Ping
AU  - Liu P
FAU - Yan, Juan-Juan
AU  - Yan JJ
FAU - Liu, Ming-Yue
AU  - Liu MY
FAU - Zhang, Gang-Qiang
AU  - Zhang GQ
FAU - Zhou, Xiao-Jiang
AU  - Zhou XJ
FAU - Yu, Bing-Ying
AU  - Yu BY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130320
PL  - United States
TA  - J Med Food
JT  - Journal of medicinal food
JID - 9812512
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Kai-Xin-San)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Brain/*drug effects/metabolism
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cognition Disorders/*drug therapy/etiology/metabolism
MH  - Cyclic AMP Response Element-Binding Protein/metabolism
MH  - Drugs, Chinese Herbal/pharmacology/*therapeutic use
MH  - Gene Expression
MH  - Glutamic Acid/metabolism
MH  - Hippocampus/drug effects/metabolism
MH  - Learning/drug effects
MH  - Learning Disabilities/*drug therapy/etiology/metabolism
MH  - Male
MH  - Memory/drug effects
MH  - Memory Disorders/*drug therapy/etiology/metabolism
MH  - Phytotherapy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sleep Deprivation/*complications/metabolism
MH  - *Sleep, REM
MH  - gamma-Aminobutyric Acid/metabolism
EDAT- 2013/03/22 06:00
MHDA- 2013/09/18 06:00
CRDT- 2013/03/22 06:00
PHST- 2013/03/22 06:00 [entrez]
PHST- 2013/03/22 06:00 [pubmed]
PHST- 2013/09/18 06:00 [medline]
AID - 10.1089/jmf.2012.2486 [doi]
PST - ppublish
SO  - J Med Food. 2013 Apr;16(4):280-7. doi: 10.1089/jmf.2012.2486. Epub 2013 Mar 20.