PMID- 23515717
OWN - NLM
STAT- MEDLINE
DCOM- 20130722
LR  - 20220408
IS  - 1522-1466 (Electronic)
IS  - 1931-857X (Print)
IS  - 1522-1466 (Linking)
VI  - 304
IP  - 10
DP  - 2013 May 15
TI  - Tumor necrosis factor-alpha: regulation of renal function and blood pressure.
PG  - F1231-42
LID - 10.1152/ajprenal.00557.2012 [doi]
AB  - Tumor necrosis factor-alpha (TNF-alpha) is a pleiotropic cytokine that becomes elevated 
      in chronic inflammatory states such as hypertension and diabetes and has been 
      found to mediate both increases and decreases in blood pressure. High levels of 
      TNF-alpha decrease blood pressure, whereas moderate increases in TNF-alpha have been 
      associated with increased NaCl retention and hypertension. The explanation for 
      these disparate effects is not clear but could simply be due to different 
      concentrations of TNF-alpha within the kidney, the physiological status of the 
      subject, or the type of stimulus initiating the inflammatory response. TNF-alpha 
      alters renal hemodynamics and nephron transport, affecting both activity and 
      expression of transporters. It also mediates organ damage by stimulating immune 
      cell infiltration and cell death. Here we will summarize the available findings 
      and attempt to provide plausible explanations for such discrepancies.
FAU - Ramseyer, Vanesa D
AU  - Ramseyer VD
AD  - Hypertension and Vascular Research Division, Department of Internal Medicine, 
      Henry Ford Hospital, Detroit, MI 48202, USA. vramsey1@hfhs.org
FAU - Garvin, Jeffrey L
AU  - Garvin JL
LA  - eng
GR  - R01 HL070985/HL/NHLBI NIH HHS/United States
GR  - HL-070985/HL/NHLBI NIH HHS/United States
GR  - HL-090550/HL/NHLBI NIH HHS/United States
GR  - HL-028982/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20130320
PL  - United States
TA  - Am J Physiol Renal Physiol
JT  - American journal of physiology. Renal physiology
JID - 100901990
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Blood Pressure/*physiology
MH  - Hemodynamics/physiology
MH  - Humans
MH  - Hypertension/metabolism/*physiopathology
MH  - Kidney/*physiology
MH  - Tumor Necrosis Factor-alpha/*physiology
PMC - PMC3651627
OTO - NOTNLM
OT  - TNF receptor
OT  - TNF-alpha
OT  - blood pressure
OT  - hypertension
OT  - natriuresis
OT  - renal hemodynamics
OT  - septic shock
OT  - transport
EDAT- 2013/03/22 06:00
MHDA- 2013/07/23 06:00
PMCR- 2014/05/15
CRDT- 2013/03/22 06:00
PHST- 2013/03/22 06:00 [entrez]
PHST- 2013/03/22 06:00 [pubmed]
PHST- 2013/07/23 06:00 [medline]
PHST- 2014/05/15 00:00 [pmc-release]
AID - ajprenal.00557.2012 [pii]
AID - F-00557-2012 [pii]
AID - 10.1152/ajprenal.00557.2012 [doi]
PST - ppublish
SO  - Am J Physiol Renal Physiol. 2013 May 15;304(10):F1231-42. doi: 
      10.1152/ajprenal.00557.2012. Epub 2013 Mar 20.