PMID- 23517773
OWN - NLM
STAT- MEDLINE
DCOM- 20130930
LR  - 20161018
IS  - 1768-3122 (Electronic)
IS  - 0248-8663 (Linking)
VI  - 34
IP  - 4
DP  - 2013 Apr
TI  - [Paradoxical reactions induced by antituberculous drugs in non-HIV infected 
      patients: a cases series of four patients and literature review].
PG  - 202-8
LID - S0248-8663(12)00667-4 [pii]
LID - 10.1016/j.revmed.2012.08.014 [doi]
AB  - INTRODUCTION: The features of paradoxical reactions (PR) that occurred in non-HIV 
      infected patients treated with antituberculous drugs are diverse. We report four 
      new cases of such PR and review the literature. PATIENTS AND METHODS: Were 
      included all consecutive patients with PR that occurred in non-HIV infected 
      patients who were treated for tuberculosis and followed-up in the department of 
      internal medicine and infectious diseases between January 1st, 2009 and July 
      31st, 2010. RESULTS: Three of the patients were male. Their median age was 28.5 
      years. Tuberculous locations were pulmonary (two instances) and extrapulmonary 
      (three instances). Paradoxical reactions occurred after a median of 5.5 weeks 
      after initiation of antituberculous treatment. The PR presented as hypercalcemia 
      (n=1), spondylitis of the 9th thoracic vertebra (n=1), intracerebral tuberculoma 
      (n=1), pericardial effusion (n=1) and adenitis (n=3). Lymphopenia was present in 
      three patients. Three out of the four patients received corticosteroid. Outcome 
      was favorable in three patients. CONCLUSION: Pardoxical reactions are more common 
      in patients who present with extrapulmonary tuberculosis. Intracerebral 
      tuberculomas and spondylitis may be asymptomatic. Prescription of corticosteroids 
      remains controversial except for intracerebral tuberculoma.
CI  - Copyright (c) 2012 Societe nationale francaise de medecine interne (SNFMI). 
      Published by Elsevier SAS. All rights reserved.
FAU - Rakotoarivelo, R A
AU  - Rakotoarivelo RA
AD  - Service de medecine interne et maladies infectieuses, hopital Saint-Andre, 1, rue 
      Jean-Burguet, 33075 Bordeaux, France. rakotoarivelo.rivo@yahoo.fr
FAU - Vandenhende, M-A
AU  - Vandenhende MA
FAU - Michaux, C
AU  - Michaux C
FAU - Morlat, P
AU  - Morlat P
FAU - Bonnet, F
AU  - Bonnet F
LA  - fre
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Reactions paradoxales sous traitement antituberculeux chez des personnes non 
      infectees par le VIH : quatre nouvelles observations et revue de la litterature.
DEP - 20130319
PL  - France
TA  - Rev Med Interne
JT  - La Revue de medecine interne
JID - 8101383
RN  - 0 (Antitubercular Agents)
RN  - 0 (Glucocorticoids)
SB  - IM
MH  - Adult
MH  - Antitubercular Agents/*adverse effects
MH  - Female
MH  - Glucocorticoids/therapeutic use
MH  - Humans
MH  - Hypercalcemia/chemically induced
MH  - Lymphadenitis/chemically induced
MH  - Lymphopenia/chemically induced
MH  - Male
MH  - Pericardial Effusion/chemically induced
MH  - Retrospective Studies
MH  - Spondylitis/chemically induced
MH  - Thoracic Vertebrae
MH  - Tuberculoma, Intracranial/chemically induced
EDAT- 2013/03/23 06:00
MHDA- 2013/10/01 06:00
CRDT- 2013/03/23 06:00
PHST- 2011/10/18 00:00 [received]
PHST- 2012/08/06 00:00 [revised]
PHST- 2012/08/19 00:00 [accepted]
PHST- 2013/03/23 06:00 [entrez]
PHST- 2013/03/23 06:00 [pubmed]
PHST- 2013/10/01 06:00 [medline]
AID - S0248-8663(12)00667-4 [pii]
AID - 10.1016/j.revmed.2012.08.014 [doi]
PST - ppublish
SO  - Rev Med Interne. 2013 Apr;34(4):202-8. doi: 10.1016/j.revmed.2012.08.014. Epub 
      2013 Mar 19.