PMID- 23517778
OWN - NLM
STAT- MEDLINE
DCOM- 20130603
LR  - 20131121
IS  - 1879-0631 (Electronic)
IS  - 0024-3205 (Linking)
VI  - 92
IP  - 14-16
DP  - 2013 May 2
TI  - Single early prenatal lipopolysaccharide exposure impairs striatal monoamines and 
      maternal care in female rats.
PG  - 852-8
LID - S0024-3205(13)00171-9 [pii]
LID - 10.1016/j.lfs.2013.03.003 [doi]
AB  - AIMS: Environmental information received by a mother can induce a phenotype 
      change in her offspring, commonly known as a maternal effect (trans-generational 
      effect). The present work verified the effects of lipopolysaccharide (LPS), which 
      mimics bacterial infection, on maternal care and on the activity of related brain 
      areas in F1 offspring, i.e., female rats that were prenatally exposed to LPS. 
      MAIN METHODS: Pregnant rats received 100mug/kg of LPS intraperitoneally on 
      gestational day (GD) 9.5. Female offspring of the F1 generation were mated to 
      naive males and were evaluated during their lactation period for open field, 
      maternal and aggressive behaviors. Striatal and hypothalamic dopamine and 
      serotonin levels and turnover were also evaluated. Furthermore, astrocyte protein 
      expression in the nucleus accumbens (NA) was analyzed in F1 females to assess 
      LPS-induced neuroinflammation. KEY FINDINGS: Prenatal LPS did not change open 
      field behavior but impaired both maternal and maternal aggressive behaviors in 
      the F1 generation. LPS exposure also reduced both striatal levels of dopamine and 
      serotonin and its metabolites, but induced no changes in NA astrocyte expression. 
      SIGNIFICANCE: We suggested that the observed impairments in the F1 females were a 
      consequence of a motivational change induced by prenatal LPS, as (1) no changes 
      in motor activity were observed, (2) prenatal LPS-exposure was reported by our 
      group to induce motivational impairments in males, and (3) the existence of a 
      strong connection between striatal dopaminergic activity and motivation-oriented 
      activities. The present findings strongly indicate a maternal effect for prenatal 
      LPS, at least for the F1 generation.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Soto, Ana M S
AU  - Soto AM
AD  - Health Sciences Institute, Paulista University, Rua Dr. Bacelar, 1212, 04026-002, 
      Sao Paulo, SP, Brazil.
FAU - Kirsten, Thiago B
AU  - Kirsten TB
FAU - Reis-Silva, Thiago M
AU  - Reis-Silva TM
FAU - Martins, Maria F M
AU  - Martins MF
FAU - Teodorov, Elisabeth
AU  - Teodorov E
FAU - Florio, Jorge C
AU  - Florio JC
FAU - Palermo-Neto, Joao
AU  - Palermo-Neto J
FAU - Bernardi, Maria M
AU  - Bernardi MM
FAU - Bondan, Eduardo F
AU  - Bondan EF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130319
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Lipopolysaccharides)
RN  - 333DO1RDJY (Serotonin)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Bacterial Infections/complications
MH  - *Behavior, Animal
MH  - Corpus Striatum/metabolism
MH  - Disease Models, Animal
MH  - Dopamine/*metabolism
MH  - Female
MH  - Hypothalamus/metabolism
MH  - Lipopolysaccharides/toxicity
MH  - Male
MH  - Maternal Behavior/*psychology
MH  - Motor Activity
MH  - Nucleus Accumbens/metabolism
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/physiopathology
MH  - Prenatal Exposure Delayed Effects/etiology/*psychology
MH  - Rats
MH  - Rats, Wistar
MH  - Serotonin/*metabolism
EDAT- 2013/03/23 06:00
MHDA- 2013/06/05 06:00
CRDT- 2013/03/23 06:00
PHST- 2013/01/16 00:00 [received]
PHST- 2013/02/19 00:00 [revised]
PHST- 2013/03/02 00:00 [accepted]
PHST- 2013/03/23 06:00 [entrez]
PHST- 2013/03/23 06:00 [pubmed]
PHST- 2013/06/05 06:00 [medline]
AID - S0024-3205(13)00171-9 [pii]
AID - 10.1016/j.lfs.2013.03.003 [doi]
PST - ppublish
SO  - Life Sci. 2013 May 2;92(14-16):852-8. doi: 10.1016/j.lfs.2013.03.003. Epub 2013 
      Mar 19.