PMID- 23518163
OWN - NLM
STAT- MEDLINE
DCOM- 20140404
LR  - 20130322
IS  - 1773-0449 (Electronic)
IS  - 1156-5233 (Linking)
VI  - 22
IP  - 4
DP  - 2012 Dec
TI  - Risk factors of Candida colonization in the oropharynx of patients admitted to an 
      intensive care unit.
PG  - 301-7
LID - S1156-5233(12)00143-6 [pii]
LID - 10.1016/j.mycmed.2012.08.001 [doi]
AB  - OBJECTIVES: Candida colonization is an important precursor for candidiasis. 
      However, there is little information about its risk factors in critically ill 
      patients. We aimed to identify risk factors for oropharyngeal Candida 
      colonization in critically ill patients. PATIENTS, MATERIALS AND METHODS: This is 
      a prospective observational study of 110 patients admitted to a medical intensive 
      care unit (MICU). Oropharyngeal swabs were obtained on day one and day four. 
      Characteristics of patients colonized with Candida species at admission or not 
      colonized were compared. In addition, patients becoming colonized during their 
      ICU stay were compared to patients who did not. RESULTS: Independent risk factors 
      for a positive Candida sample at the time of admission were: a history of proton 
      pump inhibitor (PPI) use before admission (OR: 5.24, 95% CI: 1.36-20.19), the 
      presence of diabetes mellitus (OR: 2.84, 95%CI: 1.02-7.92) and a lower BMI (OR: 
      0.9, 95% CI: 0.84-0.97). Chronic kidney disease was associated with a decreased 
      frequency of Candida colonization (OR: 0.26, 95% CI: 0.01-0.46). No independent 
      risk factors could be identified for patients who gained Candida during their ICU 
      hospitalization. Patients with Candida colonization frequently had abnormal oral 
      bacterial flora. CONCLUSIONS: Diabetes mellitus, PPI use and a lower BMI are risk 
      factors for Candida colonization in critically ill patients being admitted to the 
      MICU.
CI  - Copyright (c) 2012. Published by Elsevier SAS.
FAU - Mojazi Amiri, H
AU  - Mojazi Amiri H
AD  - Department of Internal Medicine, Texas Tech University Health Sciences Center, 
      Lubbock , TX United States.
FAU - Frandah, W
AU  - Frandah W
FAU - Colmer-Hamood, J
AU  - Colmer-Hamood J
FAU - Raj, R
AU  - Raj R
FAU - Nugent, K
AU  - Nugent K
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20121024
PL  - France
TA  - J Mycol Med
JT  - Journal de mycologie medicale
JID - 9425651
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - APACHE
MH  - Adult
MH  - Body Mass Index
MH  - Candida/*isolation & purification
MH  - Comorbidity
MH  - Critical Illness
MH  - Cross Infection/epidemiology
MH  - Diabetes Mellitus/epidemiology
MH  - Disease Susceptibility
MH  - Female
MH  - Humans
MH  - Immunocompromised Host
MH  - *Intensive Care Units
MH  - Kidney Diseases/epidemiology
MH  - Length of Stay/statistics & numerical data
MH  - Male
MH  - Middle Aged
MH  - Mouth/microbiology
MH  - Oropharynx/*microbiology
MH  - Prospective Studies
MH  - Proton Pump Inhibitors/adverse effects/therapeutic use
MH  - Risk Factors
EDAT- 2013/03/23 06:00
MHDA- 2014/04/05 06:00
CRDT- 2013/03/23 06:00
PHST- 2012/04/19 00:00 [received]
PHST- 2012/08/18 00:00 [revised]
PHST- 2012/08/19 00:00 [accepted]
PHST- 2013/03/23 06:00 [entrez]
PHST- 2013/03/23 06:00 [pubmed]
PHST- 2014/04/05 06:00 [medline]
AID - S1156-5233(12)00143-6 [pii]
AID - 10.1016/j.mycmed.2012.08.001 [doi]
PST - ppublish
SO  - J Mycol Med. 2012 Dec;22(4):301-7. doi: 10.1016/j.mycmed.2012.08.001. Epub 2012 
      Oct 24.