PMID- 23519010
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130325
LR  - 20211021
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 7
DP  - 2013
TI  - Molecular and neural bases underlying roles of BDNF in the control of body 
      weight.
PG  - 37
LID - 10.3389/fnins.2013.00037 [doi]
LID - 37
AB  - Brain-derived neurotrophic factor (BDNF) is a potent regulator of neuronal 
      development and synaptic plasticity that is fundamental to neural circuit 
      formation and cognition. It is also involved in the control of appetite and body 
      weight, with mutations in the genes for BDNF and its receptor, TrkB, resulting in 
      remarkable hyperphagia and severe obesity in humans and mice. Recent studies have 
      made significant progress in elucidating the source, action sites, and regulatory 
      pathways of BDNF with regard to its role in the control of energy homeostasis, 
      and have shed light on the relationships between BDNF and other molecules 
      involved in the control of body weight. Here we provide a comprehensive review of 
      evidence from pharmacological, genetic, and mechanistic studies, linking BDNF to 
      the control of body weight. This review also aims to organize the main findings 
      on this subject into a more refined framework and to discuss the future research 
      directions necessary to advance the field.
FAU - Vanevski, Filip
AU  - Vanevski F
AD  - Department of Pharmacology and Physiology, Georgetown University Medical Center 
      Washington, DC, USA.
FAU - Xu, Baoji
AU  - Xu B
LA  - eng
GR  - R01 DK089237/DK/NIDDK NIH HHS/United States
PT  - Journal Article
DEP - 20130321
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC3604627
OTO - NOTNLM
OT  - TrkB
OT  - brain-derived neurotrophic factor
OT  - dorsal vagal complex
OT  - energy expenditure
OT  - obesity
OT  - paraventricular hypothalamus
OT  - ventromedial hypothalamus
EDAT- 2013/03/23 06:00
MHDA- 2013/03/23 06:01
PMCR- 2013/01/01
CRDT- 2013/03/23 06:00
PHST- 2012/12/30 00:00 [received]
PHST- 2013/03/03 00:00 [accepted]
PHST- 2013/03/23 06:00 [entrez]
PHST- 2013/03/23 06:00 [pubmed]
PHST- 2013/03/23 06:01 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2013.00037 [doi]
PST - epublish
SO  - Front Neurosci. 2013 Mar 21;7:37. doi: 10.3389/fnins.2013.00037. eCollection 
      2013.