PMID- 23519767
OWN - NLM
STAT- MEDLINE
DCOM- 20131119
LR  - 20130514
IS  - 1866-3370 (Print)
IS  - 1866-3370 (Linking)
VI  - 15
DP  - 2013
TI  - Neurotrophins and synaptic plasticity.
PG  - 117-36
LID - 10.1007/7854_2012_231 [doi]
AB  - It has been suggested that long-term modifications of synaptic transmission 
      constitute the foundation of the processes by which information is stored in the 
      central nervous system. A group of proteins called neurotrophins are considered 
      powerful molecular mediators in central synaptic plasticity. Among these, 
      brain-derived neurotrophic factor (BDNF) as well as neurotrophin-3 (NT-3) have 
      emerged as having key roles in the neurobiological mechanisms related to learning 
      and memory. In this chapter, we review the studies that have represented a 
      significant step forward in understanding the role played by BDNF and NT-3 in 
      long-term synaptic plasticity. The effects of BDNF and NT-3 on synaptic 
      plasticity can be of a permissive nature, establishing the conditions under which 
      plastic changes can take place, or it may be instructive, directly modifying the 
      communication and morphology of synapses. The actions carried out by BDNF include 
      its capacity to contribute to the stabilization and maturation of 
      already-existing synapses, as well as to generate new synaptic contacts. One 
      important finding that highlights the participation of these neurotrophins in 
      synaptic plasticity is the observation that adding BDNF or NT-3 gives rise to 
      drastic long-term increases in synaptic transmission, similar to the long-term 
      potentiation in the hippocampus and neocortex of mammals. Because neurotrophins 
      modulate both the electrical properties and the structural organization of the 
      synapse, these proteins have been considered important biological markers of 
      learning and memory processes.
FAU - Gomez-Palacio-Schjetnan, Andrea
AU  - Gomez-Palacio-Schjetnan A
AD  - Division de Investigacion y Estudios de Posgrado, Facultad de Psicologia, 
      Universidad Nacional Autonoma de Mexico, 04510, Mexico, D.F., Mexico.
FAU - Escobar, Martha L
AU  - Escobar ML
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Germany
TA  - Curr Top Behav Neurosci
JT  - Current topics in behavioral neurosciences
JID - 101535383
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neurotrophin 3)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*physiology
MH  - Brain/metabolism/*physiology
MH  - Brain-Derived Neurotrophic Factor/metabolism/*physiology
MH  - Neuronal Plasticity/*physiology
MH  - Neurotrophin 3/metabolism/*physiology
MH  - Synapses/metabolism/*physiology
MH  - Synaptic Transmission/*physiology
EDAT- 2013/03/23 06:00
MHDA- 2013/11/20 06:00
CRDT- 2013/03/23 06:00
PHST- 2013/03/23 06:00 [entrez]
PHST- 2013/03/23 06:00 [pubmed]
PHST- 2013/11/20 06:00 [medline]
AID - 10.1007/7854_2012_231 [doi]
PST - ppublish
SO  - Curr Top Behav Neurosci. 2013;15:117-36. doi: 10.1007/7854_2012_231.