PMID- 23520053
OWN - NLM
STAT- MEDLINE
DCOM- 20140311
LR  - 20160511
IS  - 2042-6984 (Electronic)
IS  - 2042-6976 (Linking)
VI  - 3
IP  - 8
DP  - 2013 Aug
TI  - Mucosal brush biopsy of the oral cavity to detect local, peanut-specific 
      immunoglobulin E.
PG  - 636-41
LID - 10.1002/alr.21164 [doi]
AB  - BACKGROUND: This study compares the ability of mucosal brush biopsy (MBB) from 2 
      separate locations in the oral cavity to detect peanut-specific immunoglobulin E 
      (IgE) in patients who report adverse oral cavity reactions when ingesting 
      peanuts. METHODS: Twenty patients who reported a history of oral cavity itching 
      or swelling when ingesting peanuts underwent either MBB of the dorsal tongue (n = 
      10) or the vestibule (n = 10). Serum testing for total and peanut-specific IgE, 
      using standard immunofluorescent assay, was obtained for all patients. Total and 
      specific IgE for each location were compared. Additionally, the correlation 
      between MBB and peanut-specific IgE on serum was determined using Fisher's exact 
      probability testing. RESULTS: Peanut-specific IgE was detected in 3 of 10 (30%) 
      MBB specimens from the dorsal tongue and in 10 of 10 (100%) MBB specimens from 
      the vestibule. The mean peanut-specific IgE on MBB (kU/L) in the dorsal tongue 
      group was 0.03 vs 0.17 in the vestibule group (p = 0.0002). No significant 
      association was noted for peanut-specific IgE between MBB and serum testing (p = 
      1.0). CONCLUSION: This study demonstrates for the first time that peanut-specific 
      IgE can be detected using MBB in the oral cavity of patients who are symptomatic 
      when consuming peanuts. The vestibule was a superior location compared to the 
      dorsal tongue for oral cavity MBB, correlating very well with self-reported 
      symptoms. Peanut-specific IgE on MBB overall did not correlate well with serum 
      testing for peanut-specific IgE.
CI  - (c) 2013 ARS-AAOA, LLC.
FAU - Reisacher, William R
AU  - Reisacher WR
AD  - Department of Otolaryngology-Head and Neck Surgery, Weill Cornell Medical 
      College, New York, NY 10021, USA. wir2011@med.cornell.edu
FAU - Cohen, Justin C
AU  - Cohen JC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130320
PL  - United States
TA  - Int Forum Allergy Rhinol
JT  - International forum of allergy & rhinology
JID - 101550261
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Biopsy/methods
MH  - Fluoroimmunoassay
MH  - Humans
MH  - Immunoglobulin E/*analysis/blood
MH  - Mouth/immunology/*pathology
MH  - Mouth Mucosa/immunology/*pathology
MH  - Peanut Hypersensitivity/diagnosis/*immunology
OTO - NOTNLM
OT  - IgE
OT  - antigen
OT  - mucosal brush biopsy
OT  - oral cavity
OT  - peanut allergy
EDAT- 2013/03/23 06:00
MHDA- 2014/03/13 06:00
CRDT- 2013/03/23 06:00
PHST- 2012/11/29 00:00 [received]
PHST- 2013/01/23 00:00 [revised]
PHST- 2013/02/10 00:00 [accepted]
PHST- 2013/03/23 06:00 [entrez]
PHST- 2013/03/23 06:00 [pubmed]
PHST- 2014/03/13 06:00 [medline]
AID - 10.1002/alr.21164 [doi]
PST - ppublish
SO  - Int Forum Allergy Rhinol. 2013 Aug;3(8):636-41. doi: 10.1002/alr.21164. Epub 2013 
      Mar 20.