PMID- 23521884
OWN - NLM
STAT- MEDLINE
DCOM- 20130517
LR  - 20220129
IS  - 1097-4180 (Electronic)
IS  - 1074-7613 (Linking)
VI  - 38
IP  - 3
DP  - 2013 Mar 21
TI  - A molecular basis for the control of preimmune escape variants by HIV-specific 
      CD8+ T cells.
PG  - 425-36
LID - S1074-7613(13)00106-4 [pii]
LID - 10.1016/j.immuni.2012.11.021 [doi]
AB  - The capacity of the immune system to adapt to rapidly evolving viruses is a 
      primary feature of effective immunity, yet its molecular basis is unclear. Here, 
      we investigated protective HIV-1-specific CD8+ T cell responses directed against 
      the immunodominant p24 Gag-derived epitope KK10 (KRWIILGLNK263-272) presented by 
      human leukocyte antigen (HLA)-B *2705. We found that cross-reactive CD8+ T cell 
      clonotypes were mobilized to counter the rapid emergence of HIV-1 variants that 
      can directly affect T cell receptor (TCR) recognition. These newly recruited 
      clonotypes expressed TCRs that engaged wild-type and mutant KK10 antigens with 
      similar affinities and almost identical docking modes, thereby accounting for 
      their antiviral efficacy in HLA-B *2705+ individuals. A protective CD8+ T cell 
      repertoire therefore encompasses the capacity to control TCR-accessible 
      mutations, ultimately driving the development of more complex viral escape 
      variants that disrupt antigen presentation.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Ladell, Kristin
AU  - Ladell K
AD  - Institute of Infection and Immunity, Cardiff University School of Medicine, Heath 
      Park, Cardiff CF14 4XN, Wales, UK.
FAU - Hashimoto, Masao
AU  - Hashimoto M
FAU - Iglesias, Maria Candela
AU  - Iglesias MC
FAU - Wilmann, Pascal G
AU  - Wilmann PG
FAU - McLaren, James E
AU  - McLaren JE
FAU - Gras, Stephanie
AU  - Gras S
FAU - Chikata, Takayuki
AU  - Chikata T
FAU - Kuse, Nozomi
AU  - Kuse N
FAU - Fastenackels, Solene
AU  - Fastenackels S
FAU - Gostick, Emma
AU  - Gostick E
FAU - Bridgeman, John S
AU  - Bridgeman JS
FAU - Venturi, Vanessa
AU  - Venturi V
FAU - Arkoub, Zaina Ait
AU  - Arkoub ZA
FAU - Agut, Henri
AU  - Agut H
FAU - van Bockel, David J
AU  - van Bockel DJ
FAU - Almeida, Jorge R
AU  - Almeida JR
FAU - Douek, Daniel C
AU  - Douek DC
FAU - Meyer, Laurence
AU  - Meyer L
FAU - Venet, Alain
AU  - Venet A
FAU - Takiguchi, Masafumi
AU  - Takiguchi M
FAU - Rossjohn, Jamie
AU  - Rossjohn J
FAU - Price, David A
AU  - Price DA
FAU - Appay, Victor
AU  - Appay V
LA  - eng
GR  - 100326/Wellcome Trust/United Kingdom
GR  - BB/H001085/1/BB_/Biotechnology and Biological Sciences Research Council/United 
      Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Immunity
JT  - Immunity
JID - 9432918
RN  - 0 (Epitopes, T-Lymphocyte)
RN  - 0 (HIV Core Protein p24)
RN  - 0 (HLA-B*27:05 antigen)
RN  - 0 (HLA-B27 Antigen)
RN  - 0 (Immunodominant Epitopes)
RN  - 0 (Receptors, Antigen, T-Cell)
RN  - 0 (p24 protein, Human Immunodeficiency Virus Type 1)
SB  - IM
MH  - Amino Acid Sequence
MH  - Antigen Presentation/immunology
MH  - CD8-Positive T-Lymphocytes/*immunology/metabolism/virology
MH  - Clone Cells/immunology/metabolism/virology
MH  - Crystallography, X-Ray
MH  - Epitopes, T-Lymphocyte/chemistry/immunology/metabolism
MH  - HIV Core Protein p24/genetics/immunology/metabolism
MH  - HIV Infections/*immunology/virology
MH  - HIV-1/genetics/*immunology/metabolism
MH  - HLA-B27 Antigen/chemistry/*immunology/metabolism
MH  - Humans
MH  - Immunodominant Epitopes/chemistry/immunology/metabolism
MH  - Models, Molecular
MH  - Molecular Sequence Data
MH  - Mutation
MH  - Protein Binding/immunology
MH  - Protein Structure, Tertiary
MH  - Receptors, Antigen, T-Cell/genetics/immunology/metabolism
EDAT- 2013/03/26 06:00
MHDA- 2013/05/18 06:00
CRDT- 2013/03/26 06:00
PHST- 2012/03/24 00:00 [received]
PHST- 2012/11/05 00:00 [accepted]
PHST- 2013/03/26 06:00 [entrez]
PHST- 2013/03/26 06:00 [pubmed]
PHST- 2013/05/18 06:00 [medline]
AID - S1074-7613(13)00106-4 [pii]
AID - 10.1016/j.immuni.2012.11.021 [doi]
PST - ppublish
SO  - Immunity. 2013 Mar 21;38(3):425-36. doi: 10.1016/j.immuni.2012.11.021.