PMID- 23523973
OWN - NLM
STAT- MEDLINE
DCOM- 20140311
LR  - 20130902
IS  - 1873-6815 (Electronic)
IS  - 0531-5565 (Linking)
VI  - 48
IP  - 10
DP  - 2013 Oct
TI  - Facts and controversies in our understanding of how caloric restriction impacts 
      the mitochondrion.
PG  - 1075-84
LID - S0531-5565(13)00081-8 [pii]
LID - 10.1016/j.exger.2013.03.004 [doi]
AB  - Caloric restriction (CR) has pronounced benefits in promoting healthy aging. 
      Amongst the most frequently implicated physiological mechanisms implicated in 
      this benefit is altered mitochondrial function. Whereas a reduction in 
      mitochondrial reactive oxygen species (ROS) production is a widely consistent 
      effect of CR, an increase in mitochondrial biogenesis, which is accepted by many 
      as fact, is contradicted on several levels, most critically by a lack of increase 
      in mitochondrial protein synthesis rate in vivo. Furthermore, an increase in 
      PGC-1alpha protein and markers of mitochondrial content with CR is a highly variable 
      observation between studies. On the other hand, deacetylation of several 
      mitochondrial proteins by the sirtuin, Sirt3, is an increasingly reported 
      observation and at least so far, this observation is consistent between studies. 
      Notwithstanding this point, the controversies evident in the published literature 
      underscore the significant questions that remain in our understanding of how CR 
      impacts the mitochondrion and suggest we have yet to fully understand the 
      complexities herein.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Gouspillou, Gilles
AU  - Gouspillou G
AD  - McGill University Health Center, Department of Kinesiology, McGill University, 
      Montreal, QC, Canada.
FAU - Hepple, Russell T
AU  - Hepple RT
LA  - eng
GR  - MOP119583/Canadian Institutes of Health Research/Canada
GR  - MOP57808/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20130321
PL  - England
TA  - Exp Gerontol
JT  - Experimental gerontology
JID - 0047061
RN  - 0 (Cardiolipins)
RN  - 0 (DNA, Mitochondrial)
RN  - 0 (Reactive Oxygen Species)
RN  - EC 3.5.1.- (Sirtuins)
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - *Caloric Restriction
MH  - Cardiolipins/physiology
MH  - DNA, Mitochondrial/physiology
MH  - Humans
MH  - Mitochondria/*metabolism/physiology
MH  - Mitochondrial Turnover/physiology
MH  - Rats
MH  - Reactive Oxygen Species/metabolism
MH  - Sirtuins/physiology
OTO - NOTNLM
OT  - Aging
OT  - Caloric restriction
OT  - Mitochondria
OT  - PGC-1a
OT  - Sarcopenia
OT  - Sirtuin
EDAT- 2013/03/26 06:00
MHDA- 2014/03/13 06:00
CRDT- 2013/03/26 06:00
PHST- 2012/11/30 00:00 [received]
PHST- 2013/02/26 00:00 [revised]
PHST- 2013/03/11 00:00 [accepted]
PHST- 2013/03/26 06:00 [entrez]
PHST- 2013/03/26 06:00 [pubmed]
PHST- 2014/03/13 06:00 [medline]
AID - S0531-5565(13)00081-8 [pii]
AID - 10.1016/j.exger.2013.03.004 [doi]
PST - ppublish
SO  - Exp Gerontol. 2013 Oct;48(10):1075-84. doi: 10.1016/j.exger.2013.03.004. Epub 
      2013 Mar 21.