PMID- 23524090
OWN - NLM
STAT- MEDLINE
DCOM- 20131126
LR  - 20181202
IS  - 1879-0712 (Electronic)
IS  - 0014-2999 (Linking)
VI  - 707
IP  - 1-3
DP  - 2013 May 5
TI  - Antidepressant-like effect of macranthol isolated from Illicium dunnianum tutch 
      in mice.
PG  - 112-9
LID - S0014-2999(13)00200-8 [pii]
LID - 10.1016/j.ejphar.2013.03.010 [doi]
AB  - The present study was aimed to evaluate the behavioral and biochemical effects of 
      macranthol, a triphenyl lignan isolated from Illicium dunnianum. To this aim, 
      mice were treated with macranthol (10, 20 and 40 mg/kg) and then subjected to the 
      forced swimming test, tail suspension test and chronic unpredictable mild stress. 
      It was observed that macranthol significantly reduced the immobility time in the 
      forced swimming test and tail suspension test after acute (1-day) treatment, and 
      reversed the reduction of sucrose preference induced by chronic unpredictable 
      mild stress after chronic (5-week) treatment. In addition, macranthol completely 
      ameliorated the corticosterone hypersecretion by acute swim stress or chronic 
      unpredictable mild stress. Chronic macranthol treatment attenuated the reduction 
      of serotonergic neurotransmission in brain regions of frontal cortex and 
      hippocampus. Taken together, our findings suggested that macranthol produced an 
      antidepressant-like effect, which may be mediated by serotonergic and 
      neuroendocrine system. Moreover, the finding that only chronic but not acute 
      treatment enhanced brain-derived neurotrophic factor (BDNF) expression suggested 
      that macranthol did not produce a rapid antidepressant-like response and 
      long-term treatment was required in its clinical application.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Li, Jing
AU  - Li J
AD  - Department of Chemical and Pharmaceutical Engineering, College of Chemical 
      Engineering, Huaqiao University, Xiamen 361021, Fujian province, PR China.
FAU - Geng, Di
AU  - Geng D
FAU - Xu, Jiao
AU  - Xu J
FAU - Weng, Lian-Jin
AU  - Weng LJ
FAU - Liu, Qing
AU  - Liu Q
FAU - Yi, Li-Tao
AU  - Yi LT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130322
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Alkenes)
RN  - 0 (Antidepressive Agents)
RN  - 0 (Phenols)
RN  - 0 (macranthol)
RN  - 333DO1RDJY (Serotonin)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Alkenes/administration & dosage/isolation & purification/*pharmacology
MH  - Animals
MH  - Antidepressive Agents/administration & dosage/isolation & 
      purification/*pharmacology
MH  - Corticosterone/metabolism
MH  - Depression/*drug therapy
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Hindlimb Suspension
MH  - Hippocampus/drug effects/metabolism
MH  - Illicium/*chemistry
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Phenols/administration & dosage/isolation & purification/*pharmacology
MH  - Prefrontal Cortex/drug effects/metabolism
MH  - Serotonin/metabolism
MH  - Stress, Psychological/drug therapy
MH  - Swimming
MH  - Time Factors
EDAT- 2013/03/26 06:00
MHDA- 2013/12/16 06:00
CRDT- 2013/03/26 06:00
PHST- 2012/07/31 00:00 [received]
PHST- 2013/03/06 00:00 [revised]
PHST- 2013/03/07 00:00 [accepted]
PHST- 2013/03/26 06:00 [entrez]
PHST- 2013/03/26 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - S0014-2999(13)00200-8 [pii]
AID - 10.1016/j.ejphar.2013.03.010 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2013 May 5;707(1-3):112-9. doi: 10.1016/j.ejphar.2013.03.010. 
      Epub 2013 Mar 22.