PMID- 23524621
OWN - NLM
STAT- MEDLINE
DCOM- 20130620
LR  - 20211021
IS  - 0172-780X (Print)
IS  - 0172-780X (Linking)
VI  - 34
IP  - 1
DP  - 2013
TI  - Association of the Period3 clock gene length polymorphism with salivary cortisol 
      secretion among police officers.
PG  - 27-37
AB  - OBJECTIVE: This study evaluated whether measures of waking or diurnal cortisol 
      secretion, or self-reported psychological disturbances differed among police 
      officers with a Period3 (PER3) clock gene length polymorphism. METHODS: The 
      cortisol awakening response was characterized via the area under the salivary 
      cortisol curve with respect to the increase (AUCI) or total waking cortisol 
      (AUCG). Diurnal cortisol measures included the slope of diurnal cortisol and the 
      diurnal AUCG. Psychological disturbances were characterized using the Center for 
      Epidemiologic Studies Depression Scale, Impact of Events Scale, and Life Events 
      Scale. RESULTS: Officers with a 4/5 or 5/5 genotype had higher awakening AUCG and 
      greater diurnal cortisol AUCG levels compared to officers with the 4/4 genotype. 
      Among those working more afternoon or night shifts, waking AUCI and AUCG were 
      greater among officers with a 4/5 or 5/5 genotype compared to the 4/4 referents. 
      CONCLUSION: Cortisol secretion was modified among police officers with different 
      PER3 VNTR clock gene variants.
FAU - Wirth, Michael
AU  - Wirth M
AD  - Cancer Prevention and Control Program, University of South Carolina, Columbia, 
      SC, USA. wirthm@mailbox.sc.edu
FAU - Burch, James
AU  - Burch J
FAU - Violanti, John
AU  - Violanti J
FAU - Burchfiel, Cecil
AU  - Burchfiel C
FAU - Fekedulegn, Desta
AU  - Fekedulegn D
FAU - Andrew, Michael
AU  - Andrew M
FAU - Zhang, Hongmei
AU  - Zhang H
FAU - Miller, Diane B
AU  - Miller DB
FAU - Youngstedt, Shawn D
AU  - Youngstedt SD
FAU - Hebert, James R
AU  - Hebert JR
FAU - Vena, John E
AU  - Vena JE
LA  - eng
GR  - K05 CA136975/CA/NCI NIH HHS/United States
GR  - T32 GM081740/GM/NIGMS NIH HHS/United States
GR  - T32-5R18CE001240/CE/NCIPC CDC HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - Sweden
TA  - Neuro Endocrinol Lett
JT  - Neuro endocrinology letters
JID - 8008373
RN  - 0 (PER3 protein, human)
RN  - 0 (Period Circadian Proteins)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adult
MH  - Circadian Rhythm/genetics/physiology
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Hydrocortisone/*metabolism
MH  - Life Change Events
MH  - Male
MH  - Middle Aged
MH  - Period Circadian Proteins/*genetics
MH  - *Police
MH  - *Polymorphism, Genetic
MH  - Salivary Glands/metabolism
MH  - Sleep Disorders, Circadian Rhythm/*genetics/metabolism
MH  - Stress, Psychological/*genetics/metabolism
PMC - PMC3655703
MID - NIHMS462527
EDAT- 2013/03/26 06:00
MHDA- 2013/06/21 06:00
PMCR- 2013/05/16
CRDT- 2013/03/26 06:00
PHST- 2012/12/10 00:00 [received]
PHST- 2013/02/12 00:00 [accepted]
PHST- 2013/03/26 06:00 [entrez]
PHST- 2013/03/26 06:00 [pubmed]
PHST- 2013/06/21 06:00 [medline]
PHST- 2013/05/16 00:00 [pmc-release]
AID - NEL340113A04 [pii]
PST - ppublish
SO  - Neuro Endocrinol Lett. 2013;34(1):27-37.