PMID- 23526925
OWN - NLM
STAT- MEDLINE
DCOM- 20130920
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 8
IP  - 3
DP  - 2013
TI  - Increased expression of neurotrophin 4 following focal cerebral ischemia in adult 
      rat brain with treadmill exercise.
PG  - e52461
LID - 10.1371/journal.pone.0052461 [doi]
LID - e52461
AB  - Neurotrophin 4 (NT-4) belongs to the family of neurotrophic factors, and it 
      interacts with the tyrosine kinase B (trkB) receptor. NT-4 has neuroprotective 
      effects following cerebral ischemia. Its role might be similar to brain-derived 
      neurotrophic factor (BDNF), because both interact with trkB. Exercise also 
      improves neural function by increasing neurotrophic factors. However, expression 
      profiles of NT-4 in the brain during exercise are unknown. Here, we assessed the 
      expressions of NT-4 and its receptor, trkB, following cerebral ischemia and 
      hypothesized that exercise changes the expressions of NT-4 and trkB. Results 
      showed that in a permanent middle cerebral artery occlusion rat model, ischemia 
      decreased NT-4 and trkB expression. Immunohistochemistry showed their 
      immunoreactivities around the region of the ischemic area. Treadmill exercise 
      changed the expression of NT-4, which increased in the contralateral hemisphere 
      in rats with ischemic injury. TrkB also showed similar patterns to its 
      neurotophins. The change in NT-4 suggested that exercise might have primed NT4 
      production so that further injury causes slightly greater increases in NT4 
      compared with non-exercise controls.
FAU - Chung, Jin-Young
AU  - Chung JY
AD  - Department of Neurology, Seoul National University Hospital, Chongno-ku, Seoul, 
      Korea.
FAU - Kim, Min-Wook
AU  - Kim MW
FAU - Bang, Moon-Suk
AU  - Bang MS
FAU - Kim, Manho
AU  - Kim M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130318
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Nerve Growth Factors)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - P658DCA9XD (neurotrophin 4)
SB  - IM
MH  - Animals
MH  - Brain/*metabolism
MH  - Brain Ischemia/*metabolism
MH  - Immunohistochemistry
MH  - Infarction, Middle Cerebral Artery/metabolism
MH  - Male
MH  - Molecular Weight
MH  - Nerve Growth Factors/chemistry/*metabolism
MH  - Physical Exertion/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, trkB/chemistry/metabolism
PMC - PMC3601124
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2013/03/26 06:00
MHDA- 2013/09/21 06:00
PMCR- 2013/03/18
CRDT- 2013/03/26 06:00
PHST- 2012/09/15 00:00 [received]
PHST- 2012/11/19 00:00 [accepted]
PHST- 2013/03/26 06:00 [entrez]
PHST- 2013/03/26 06:00 [pubmed]
PHST- 2013/09/21 06:00 [medline]
PHST- 2013/03/18 00:00 [pmc-release]
AID - PONE-D-12-28312 [pii]
AID - 10.1371/journal.pone.0052461 [doi]
PST - ppublish
SO  - PLoS One. 2013;8(3):e52461. doi: 10.1371/journal.pone.0052461. Epub 2013 Mar 18.