PMID- 23527193
OWN - NLM
STAT- MEDLINE
DCOM- 20130920
LR  - 20221207
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 8
IP  - 3
DP  - 2013
TI  - A meta-analysis of the association between TNF-alpha -308G>A polymorphism and type 2 
      diabetes mellitus in Han Chinese population.
PG  - e59421
LID - 10.1371/journal.pone.0059421 [doi]
LID - e59421
AB  - OBJECTIVE: A meta-analysis was applied to evaluate the associations between tumor 
      necrosis factor-alpha (TNF-alpha) -308G>A (rs1800629) polymorphism and type 2 diabetes 
      mellitus (T2DM). METHODS: Hardy-Weinberg equilibrium (HWE) was employed to test 
      genetic equilibrium among the genotypes of the selected literature. Power 
      analysis was performed with the Power and Sample Size Calculation (PS) program. A 
      fixed or random effect model was used on the basis of heterogeneity. Publication 
      bias was quantified and examined with the Begg's funnel plot test and Egger's 
      linear regression test. The meta-analysis was performed with Review Manager 5.1 
      and Stata 11.0. RESULTS: There were 10 studies including 1425 T2DM patients and 
      1116 healthy control subjects involved in this meta-analysis. No significant 
      publication bias was found in the studies. The pooled ORs (95% CIs) for TNF-alpha 
      -308G>A of A vs. G allele and GA+AA vs. GG genotype were 1.63 (1.17-2.25) and 
      1.47 (1.17-1.85), respectively. CONCLUSION: This meta-analysis result suggested 
      that TNF-alpha -308G>A polymorphism was strongly associated with T2DM risk, and A 
      allele at this locus might be a susceptibility allele for the development of T2DM 
      in Han Chinese population.
FAU - Liu, Zheng-hui
AU  - Liu ZH
AD  - Department of Epidemiology and Medical Statistics, School of Public Health, 
      Guangdong Medical College, Dongguan, Guangdong, China.
FAU - Ding, Yuan-lin
AU  - Ding YL
FAU - Xiu, Liang-chang
AU  - Xiu LC
FAU - Pan, Hai-yan
AU  - Pan HY
FAU - Liang, Yan
AU  - Liang Y
FAU - Zhong, Shou-qiang
AU  - Zhong SQ
FAU - Liu, Wei-wei
AU  - Liu WW
FAU - Rao, Shao-qi
AU  - Rao SQ
FAU - Kong, Dan-li
AU  - Kong DL
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20130319
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Asian People/*genetics
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Genetic Association Studies
MH  - Genotype
MH  - Humans
MH  - Linear Models
MH  - Models, Genetic
MH  - Odds Ratio
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Publication Bias
MH  - Tumor Necrosis Factor-alpha/*genetics
PMC - PMC3601959
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2013/03/26 06:00
MHDA- 2013/09/21 06:00
PMCR- 2013/03/19
CRDT- 2013/03/26 06:00
PHST- 2012/11/28 00:00 [received]
PHST- 2013/02/14 00:00 [accepted]
PHST- 2013/03/26 06:00 [entrez]
PHST- 2013/03/26 06:00 [pubmed]
PHST- 2013/09/21 06:00 [medline]
PHST- 2013/03/19 00:00 [pmc-release]
AID - PONE-D-12-37285 [pii]
AID - 10.1371/journal.pone.0059421 [doi]
PST - ppublish
SO  - PLoS One. 2013;8(3):e59421. doi: 10.1371/journal.pone.0059421. Epub 2013 Mar 19.