PMID- 23527810
OWN - NLM
STAT- MEDLINE
DCOM- 20130613
LR  - 20191112
IS  - 1001-9294 (Print)
IS  - 1001-9294 (Linking)
VI  - 28
IP  - 1
DP  - 2013 Mar
TI  - Three times spontaneous remission of severe aplastic anemia following granulocyte 
      transfusion from related donors: a case report and literature review.
PG  - 58-60
AB  - Aplastic anemia (AA) is a bone marrow failure disease caused by abnormal 
      activation of T lymphocytes, resulting in the apoptosis of hematopoietic cells 
      and bone marrow failure. Currently, hematopoietic stem cell transplantation 
      (HSCT), immunosuppressive - therapy (IST), and supportive care (e.g. transfusion 
      adjuvant therapy, hematopoietic growth factors, and prevention of infection) are 
      the main treatments of AA. Granulocyte transfusion has recently been accepted as 
      an useful adjuvant therapy of HSCT and intensive IST. This article reported a 
      severe AA patient who failed to respond to IST, but achieved spontaneous 
      remission three times after granulocyte transfusions from related donors. Such 
      cases have rarely been reported. Existence of human leukocyte antigen (HLA) cross 
      between the patient and his relatives may influence the T cell-mediated immunity, 
      which might explain this patient's recovery.
FAU - Fang, Bao-zhi
AU  - Fang BZ
AD  - Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow 
      University, Suzhou, China.
FAU - He, Guang-sheng
AU  - He GS
FAU - Zhou, Hai-xia
AU  - Zhou HX
FAU - Chang, Hui-rong
AU  - Chang HR
FAU - Wu, De-pei
AU  - Wu DP
FAU - Sun, Ai-ning
AU  - Sun AN
FAU - Chen, Su-ning
AU  - Chen SN
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - China
TA  - Chin Med Sci J
JT  - Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih
JID - 9112559
SB  - IM
MH  - Adult
MH  - Anemia, Aplastic/immunology/*physiopathology/*therapy
MH  - Granulocytes/*transplantation
MH  - Humans
MH  - *Leukocyte Transfusion
MH  - Male
MH  - Remission, Spontaneous
EDAT- 2013/03/27 06:00
MHDA- 2013/06/14 06:00
CRDT- 2013/03/27 06:00
PHST- 2013/03/27 06:00 [entrez]
PHST- 2013/03/27 06:00 [pubmed]
PHST- 2013/06/14 06:00 [medline]
AID - 10080 [pii]
AID - 10.1016/s1001-9294(13)60021-8 [doi]
PST - ppublish
SO  - Chin Med Sci J. 2013 Mar;28(1):58-60. doi: 10.1016/s1001-9294(13)60021-8.