PMID- 23528886
OWN - NLM
STAT- MEDLINE
DCOM- 20150707
LR  - 20211021
IS  - 1422-0067 (Print)
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 14
IP  - 4
DP  - 2013 Mar 25
TI  - The multiple faces of prostaglandin E2 G-protein coupled receptor signaling 
      during the dendritic cell life cycle.
PG  - 6542-55
LID - 10.3390/ijms14046542 [doi]
AB  - Many processes regulating immune responses are initiated by G-protein coupled 
      receptors (GPCRs) and report biochemical changes in the microenvironment. 
      Dendritic cells (DCs) are the most potent antigen-presenting cells and crucial 
      for the regulation of innate and adaptive immune responses. The lipid mediator 
      Prostaglandin E2 (PGE2) via four GPCR subtypes (EP1-4) critically regulates DC 
      generation, maturation and migration. The role of PGE2 signaling in DC biology 
      was unraveled by the characterization of EP receptor subtype expression in DC 
      progenitor cells and DCs, the identification of the signaling pathways initiated 
      by these GPCR subtypes and the classification of DC responses to PGE2 at 
      different stages of differentiation. Here, we review the advances in PGE2 
      signaling in DCs and describe the efforts still to be made to understand the 
      spatio-temporal fine-tuning of PGE2 responses by DCs.
FAU - De Keijzer, Sandra
AU  - De Keijzer S
AD  - Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, 
      Radboud University Nijmegen Medical Centre, Geert Grooteplein 28, Nijmegen 
      6525GA, The Netherlands. a.cambi@ncmls.ru.nl.
FAU - Meddens, Marjolein B M
AU  - Meddens MB
FAU - Torensma, Ruurd
AU  - Torensma R
FAU - Cambi, Alessandra
AU  - Cambi A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20130325
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Receptors, G-Protein-Coupled)
RN  - K7Q1JQR04M (Dinoprostone)
SB  - IM
MH  - Animals
MH  - *Cell Cycle
MH  - Dendritic Cells/*cytology/*metabolism
MH  - Dinoprostone/*metabolism
MH  - Humans
MH  - Models, Biological
MH  - Receptors, G-Protein-Coupled/*metabolism
MH  - *Signal Transduction
PMC - PMC3645653
EDAT- 2013/03/27 06:00
MHDA- 2013/03/27 06:01
PMCR- 2013/04/01
CRDT- 2013/03/27 06:00
PHST- 2013/02/15 00:00 [received]
PHST- 2013/03/02 00:00 [revised]
PHST- 2013/03/11 00:00 [accepted]
PHST- 2013/03/27 06:00 [entrez]
PHST- 2013/03/27 06:00 [pubmed]
PHST- 2013/03/27 06:01 [medline]
PHST- 2013/04/01 00:00 [pmc-release]
AID - ijms14046542 [pii]
AID - ijms-14-06542 [pii]
AID - 10.3390/ijms14046542 [doi]
PST - epublish
SO  - Int J Mol Sci. 2013 Mar 25;14(4):6542-55. doi: 10.3390/ijms14046542.