PMID- 23531226
OWN - NLM
STAT- MEDLINE
DCOM- 20150603
LR  - 20211021
IS  - 1478-6362 (Electronic)
IS  - 1478-6354 (Print)
IS  - 1478-6354 (Linking)
VI  - 15
IP  - 2
DP  - 2013 Mar 26
TI  - Exercise training in childhood-onset systemic lupus erythematosus: a controlled 
      randomized trial.
PG  - R46
LID - 10.1186/ar4205 [doi]
AB  - INTRODUCTION: Exercise training has emerged as a promising therapeutic strategy 
      to counteract physical dysfunction in adult systemic lupus erythematosus. 
      However, no longitudinal studies have evaluated the effects of an exercise 
      training program in childhood-onset systemic lupus erythematosus (C-SLE) 
      patients. The objective was to evaluate the safety and the efficacy of a 
      supervised aerobic training program in improving the cardiorespiratory capacity 
      in C-SLE patients. METHODS: Nineteen physically inactive C-SLE patients were 
      randomly assigned into two groups: trained (TR, n = 10, supervised 
      moderate-intensity aerobic exercise program) and non-trained (NT, n = 9). 
      Gender-, body mass index (BMI)- and age-matched healthy children were recruited 
      as controls (C, n = 10) for baseline (PRE) measurements only. C-SLE patients were 
      assessed at PRE and after 12 weeks of training (POST). Main measurements included 
      exercise tolerance and cardiorespiratory measurements in response to a maximal 
      exercise (that is, peak VO2, chronotropic reserve (CR), and the heart rate 
      recovery (DeltaHRR) (that is, the difference between HR at peak exercise and at both 
      the first (DeltaHRR1) and second (DeltaHRR2) minutes of recovery after exercise). 
      RESULTS: The C-SLE NT patients did not present changes in any of the 
      cardiorespiratory parameters at POST (P > 0.05). In contrast, the exercise 
      training program was effective in promoting significant increases in 
      time-to-exhaustion (P = 0.01; ES = 1.07), peak speed (P = 0.01; ES = 1.08), peak 
      VO2 (P = 0.04; ES = 0.86), CR (P = 0.06; ES = 0.83), and in DeltaHRR1 and DeltaHRR2 (P = 
      0.003; ES = 1.29 and P = 0.0008; ES = 1.36, respectively) in the C-SLE TR when 
      compared with the NT group. Moreover, cardiorespiratory parameters were 
      comparable between C-SLE TR patients and C subjects after the exercise training 
      intervention, as evidenced by the ANOVA analysis (P > 0.05, TR vs. C). SLEDAI-2K 
      scores remained stable throughout the study. CONCLUSION: A 3-month aerobic 
      exercise training was safe and capable of ameliorating the cardiorespiratory 
      capacity and the autonomic function in C-SLE patients. TRIAL REGISTRATION: 
      NCT01515163.
FAU - Prado, Danilo M L
AU  - Prado DM
FAU - Benatti, Fabiana B
AU  - Benatti FB
FAU - de Sa-Pinto, Ana L
AU  - de Sa-Pinto AL
FAU - Hayashi, Ana P
AU  - Hayashi AP
FAU - Gualano, Bruno
AU  - Gualano B
FAU - Pereira, Rosa M R
AU  - Pereira RM
FAU - Sallum, Adriana M E
AU  - Sallum AM
FAU - Bonfa, Eloisa
AU  - Bonfa E
FAU - Silva, Clovis A
AU  - Silva CA
FAU - Roschel, Hamilton
AU  - Roschel H
LA  - eng
SI  - ClinicalTrials.gov/NCT01515163
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20130326
PL  - England
TA  - Arthritis Res Ther
JT  - Arthritis research & therapy
JID - 101154438
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Exercise Therapy/*methods
MH  - Exercise Tolerance
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Lupus Erythematosus, Systemic/*rehabilitation
MH  - Male
PMC - PMC3672722
EDAT- 2013/03/28 06:00
MHDA- 2015/06/04 06:00
PMCR- 2013/03/26
CRDT- 2013/03/28 06:00
PHST- 2012/10/17 00:00 [received]
PHST- 2013/03/19 00:00 [accepted]
PHST- 2013/03/28 06:00 [entrez]
PHST- 2013/03/28 06:00 [pubmed]
PHST- 2015/06/04 06:00 [medline]
PHST- 2013/03/26 00:00 [pmc-release]
AID - ar4205 [pii]
AID - 10.1186/ar4205 [doi]
PST - epublish
SO  - Arthritis Res Ther. 2013 Mar 26;15(2):R46. doi: 10.1186/ar4205.