PMID- 23531279
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130410
LR  - 20220316
IS  - 1743-7075 (Print)
IS  - 1743-7075 (Electronic)
IS  - 1743-7075 (Linking)
VI  - 10
IP  - 1
DP  - 2013 Mar 27
TI  - Caloric restriction favorably impacts metabolic and immune/inflammatory profiles 
      in obese mice but curcumin/piperine consumption adds no further benefit.
PG  - 29
LID - 10.1186/1743-7075-10-29 [doi]
AB  - BACKGROUND: Obesity is associated with low-grade inflammation and impaired immune 
      response. Caloric restriction (CR) has been shown to inhibit inflammatory 
      response and enhance cell-mediated immune function. Curcumin, the bioactive 
      phenolic component of turmeric spice, is proposed to have anti-obesity and 
      anti-inflammation properties while piperine, another bioactive phenolic compound 
      present in pepper spice, can enhance the bioavailability and efficacy of 
      curcumin. This study sought to determine if curcumin could potentiate CR's 
      beneficial effect on immune and inflammatory responses in obesity developed in 
      mice by feeding high-fat diet (HFD). METHODS: Mice were fed a HFD for 22 wk and 
      then randomized into 5 groups: one group remained on HFD ad libitum and the 
      remaining 4 groups were fed a 10% CR (reduced intake of HFD by 10% but 
      maintaining the same levels of micronutrients) in the presence or absence of 
      curcumin and/or piperine for 5 wk, after which CR was increased to 20% for an 
      additional 33 wk. At the end of the study, mice were sacrificed, and spleen cells 
      were isolated. Cells were stimulated with T cell mitogens, anti-CD3/CD28 
      antibodies, or lipopolysaccharide to determine T cell proliferation, cytokine 
      production, and CD4+ T cell subpopulations. RESULTS: Compared to HFD control 
      group, all CR mice, regardless of the presence of curcumin and/or piperine, had 
      lower body weight and fat mass, lower levels of blood glucose and insulin, and 
      fewer total spleen cells but a higher percentage of CD4+ T cells. Additionally, 
      they demonstrated lower production of pro-inflammatory cytokines IL-1beta and TNF-alpha, 
      a trend toward lower IL-6, and lower production of PGE2, a lipid molecule with 
      pro-inflammatory and T cell-suppressive properties. Mice with CR alone had higher 
      splenocyte proliferation and IL-2 production, but this effect of CR was 
      diminished by spice supplementation. CR alone or in combination with spice 
      supplementation had no effect on production of cytokines IL-4, IL-10, IFN-gamma, and 
      IL-17, or the proportion of different CD4+ T cell subsets. CONCLUSION: CR on an 
      HFD favorably impacts both metabolic and immune/inflammatory profiles; however, 
      the presence of curcumin and/or piperine does not amplify CR's beneficial 
      effects.
FAU - Wang, Junpeng
AU  - Wang J
AD  - Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research 
      Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, 
      USA. dayong.wu@tufts.edu.
FAU - Vanegas, Sally M
AU  - Vanegas SM
FAU - Du, Xiaogang
AU  - Du X
FAU - Noble, Timothy
AU  - Noble T
FAU - Zingg, Jean-Marc A
AU  - Zingg JM
FAU - Meydani, Mohsen
AU  - Meydani M
FAU - Meydani, Simin Nikbin
AU  - Meydani SN
FAU - Wu, Dayong
AU  - Wu D
LA  - eng
GR  - T32 DK062032/DK/NIDDK NIH HHS/United States
PT  - Journal Article
DEP - 20130327
PL  - England
TA  - Nutr Metab (Lond)
JT  - Nutrition & metabolism
JID - 101231644
PMC - PMC3621165
EDAT- 2013/03/28 06:00
MHDA- 2013/03/28 06:01
PMCR- 2013/03/27
CRDT- 2013/03/28 06:00
PHST- 2013/01/22 00:00 [received]
PHST- 2013/03/22 00:00 [accepted]
PHST- 2013/03/28 06:00 [entrez]
PHST- 2013/03/28 06:00 [pubmed]
PHST- 2013/03/28 06:01 [medline]
PHST- 2013/03/27 00:00 [pmc-release]
AID - 1743-7075-10-29 [pii]
AID - 10.1186/1743-7075-10-29 [doi]
PST - epublish
SO  - Nutr Metab (Lond). 2013 Mar 27;10(1):29. doi: 10.1186/1743-7075-10-29.