PMID- 23531353
OWN - NLM
STAT- MEDLINE
DCOM- 20130927
LR  - 20161125
IS  - 1549-4713 (Electronic)
IS  - 0161-6420 (Linking)
VI  - 120
IP  - 7
DP  - 2013 Jul
TI  - Enhanced depth imaging optical coherence tomography of optic nerve head drusen.
PG  - 1409-14
LID - S0161-6420(12)01257-2 [pii]
LID - 10.1016/j.ophtha.2012.12.035 [doi]
AB  - OBJECTIVE: To assess the value of enhanced depth imaging optical coherence 
      tomography (EDI OCT) in diagnosing and evaluating optic nerve head drusen (ONHD) 
      compared with conventional diagnostic methods. DESIGN: Prospective, comparative, 
      cross-sectional study. PARTICIPANTS: Thirty-four patients with clinically visible 
      or suspected ONHD in either eye based on dilated optic disc examination or optic 
      disc stereophotography and without ocular comorbidity. METHODS: Spectral-domain 
      OCT of the optic nerve head in both conventional (non-EDI) and EDI modes, 
      ultrasound B-scan, and standard automated perimetry were performed on both eyes 
      of all participants. MAIN OUTCOME MEASURES: Detection and findings of ONHD 
      between EDI OCT and conventional diagnostic methods. RESULTS: Sixty-eight eyes 
      were clinically classified into 3 groups: 32 eyes with definite ONHD, 25 eyes 
      with suspected ONHD, and 11 normal-appearing fellow eyes. In the definite ONHD 
      group, EDI OCT, non-EDI OCT, and ultrasound B-scan were positive for ONHD in all 
      eyes and visual field (VF) was abnormal in 24 eyes. In the suspected ONHD group, 
      EDI OCT, non-EDI OCT, ultrasound B-scan, and VF were positive in 17, 14, 7, and 3 
      eyes, respectively; 8 eyes had no evidence of ONHD in any of the tests. In 
      normal-appearing fellow eyes, EDI OCT, non-EDI OCT, ultrasound B-scan, and VF 
      were positive in 3, 1, 1, and 0 eyes, respectively; 4 eyes had no evidence of 
      ONHD in any of the tests. Enhanced depth imaging OCT had a significantly higher 
      ONHD detection rate than ultrasound B-scan in all eyes (52/68 eyes vs. 40/68 
      eyes; P<0.001), in eyes with clinically suspected ONHD or normal-appearing fellow 
      eyes (20/36 eyes vs. 8/36 eyes; P<0.001), and in eyes with clinically suspected 
      ONHD (17/25 eyes vs. 7/25 eyes; P = 0.002). Enhanced depth imaging OCT-detected 
      ONHD appeared as signal-poor regions surrounded by short, hyper-reflective bands 
      or isolated/clustered hyper-reflective bands without a signal-poor core. In 
      non-EDI OCT, posterior surfaces of the ONHD and deep-seated hyper-reflective 
      bands were invisible or less clear than in EDI OCT. CONCLUSIONS: Enhanced depth 
      imaging OCT detects lesions likely representing ONHD more often and better 
      assesses their shape and structure than conventional tests.
CI  - Copyright (c) 2013 American Academy of Ophthalmology. Published by Elsevier Inc. 
      All rights reserved.
FAU - Merchant, Kunal Y
AU  - Merchant KY
AD  - George Washington University School of Medicine and Health Sciences, Washington, 
      DC, USA.
FAU - Su, Daniel
AU  - Su D
FAU - Park, Sung Chul
AU  - Park SC
FAU - Qayum, Shehzad
AU  - Qayum S
FAU - Banik, Rudrani
AU  - Banik R
FAU - Liebmann, Jeffrey M
AU  - Liebmann JM
FAU - Ritch, Robert
AU  - Ritch R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130324
PL  - United States
TA  - Ophthalmology
JT  - Ophthalmology
JID - 7802443
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Intraocular Pressure/physiology
MH  - Male
MH  - Middle Aged
MH  - Optic Disk/diagnostic imaging/*pathology
MH  - Optic Disk Drusen/*diagnosis/diagnostic imaging
MH  - Photography
MH  - Prospective Studies
MH  - *Tomography, Optical Coherence
MH  - Ultrasonography
MH  - Visual Acuity/physiology
MH  - Visual Field Tests
MH  - Visual Fields/physiology
MH  - Young Adult
EDAT- 2013/03/28 06:00
MHDA- 2013/09/28 06:00
CRDT- 2013/03/28 06:00
PHST- 2012/08/08 00:00 [received]
PHST- 2012/12/10 00:00 [revised]
PHST- 2012/12/18 00:00 [accepted]
PHST- 2013/03/28 06:00 [entrez]
PHST- 2013/03/28 06:00 [pubmed]
PHST- 2013/09/28 06:00 [medline]
AID - S0161-6420(12)01257-2 [pii]
AID - 10.1016/j.ophtha.2012.12.035 [doi]
PST - ppublish
SO  - Ophthalmology. 2013 Jul;120(7):1409-14. doi: 10.1016/j.ophtha.2012.12.035. Epub 
      2013 Mar 24.