PMID- 23532065
OWN - NLM
STAT- MEDLINE
DCOM- 20131023
LR  - 20220318
IS  - 1473-5873 (Electronic)
IS  - 0955-8829 (Linking)
VI  - 23
IP  - 3
DP  - 2013 Jun
TI  - BDNF Val66Met polymorphism and anxiety/depression symptoms in schizophrenia in a 
      Chinese Han population.
PG  - 124-9
LID - 10.1097/YPG.0b013e328360c866 [doi]
AB  - BACKGROUND: Although several lines of evidences suggest that the brain-derived 
      neurotrophic factor (BDNF) Val66Met polymorphism may be involved in the 
      pathophysiology of schizophrenia, this association remains controversial. Here, 
      we aim to investigate the genetic association between the BDNF Val66Met 
      polymorphism and schizophrenia and to explore whether this polymorphism could 
      influence the severity of clinical symptoms in schizophrenic patients in a 
      Chinese Han population. PATIENTS AND METHODS: Genotyping of the BDNF Val66Met 
      polymorphism was carried out in 456 schizophrenic patients and 483 controls using 
      the fluorescence resonance energy transfer method. The patients' psychotic 
      symptoms were assessed using the Positive and Negative Syndrome Scale. The 
      general clinical data of schizophrenic patients were analyzed. RESULTS: There 
      were significant differences in the genotype distribution and allelic frequencies 
      of the BDNF Val66Met polymorphism between the schizophrenia group and the 
      controls. Multiple linear regression analysis showed that the BDNF Val66Met 
      polymorphism explained ~16% of the variance in anxiety/depression symptoms in 
      schizophrenic patients. CONCLUSION: Our data provide evidence that the BDNF 
      Val66Met polymorphism may be involved in the etiology of schizophrenia in a 
      Chinese Han population. Furthermore, the BDNF Val66Met polymorphism is a 
      significant factor influencing the severity of anxiety/depression symptoms in 
      schizophrenic patients.
FAU - Sun, Meng-Meng
AU  - Sun MM
AD  - Department of Psychiatry, Shandong Mental Health Center, Shandong University, 
      Jinan, Shandong, People's Republic of China.
FAU - Yang, Li-Min
AU  - Yang LM
FAU - Wang, Yan
AU  - Wang Y
FAU - Feng, Xuan
AU  - Feng X
FAU - Cui, Kai-Yan
AU  - Cui KY
FAU - Liu, Lan-Fen
AU  - Liu LF
FAU - Chen, Zhe-Yu
AU  - Chen ZY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Psychiatr Genet
JT  - Psychiatric genetics
JID - 9106748
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adult
MH  - Anxiety/complications/ethnology/*genetics
MH  - Brain-Derived Neurotrophic Factor/chemistry/*genetics
MH  - Case-Control Studies
MH  - China
MH  - Depression/complications/enzymology/*genetics
MH  - Ethnicity
MH  - Female
MH  - Humans
MH  - Linear Models
MH  - Male
MH  - Methionine/*genetics
MH  - *Polymorphism, Genetic
MH  - Schizophrenia/complications/enzymology/*genetics
MH  - Valine/*genetics
EDAT- 2013/03/28 06:00
MHDA- 2013/10/24 06:00
CRDT- 2013/03/28 06:00
PHST- 2013/03/28 06:00 [entrez]
PHST- 2013/03/28 06:00 [pubmed]
PHST- 2013/10/24 06:00 [medline]
AID - 10.1097/YPG.0b013e328360c866 [doi]
PST - ppublish
SO  - Psychiatr Genet. 2013 Jun;23(3):124-9. doi: 10.1097/YPG.0b013e328360c866.