PMID- 23532066
OWN - NLM
STAT- MEDLINE
DCOM- 20131023
LR  - 20130422
IS  - 1473-5873 (Electronic)
IS  - 0955-8829 (Linking)
VI  - 23
IP  - 3
DP  - 2013 Jun
TI  - BDNF polymorphism rs11030101 is associated with the efficacy of electroconvulsive 
      therapy in treatment-resistant depression.
PG  - 134-6
LID - 10.1097/YPG.0b013e328360c894 [doi]
AB  - The aim of the present study was to test for a possible association between two 
      brain-derived neurotrophic factor (BDNF) polymorphisms (rs11030101 and 
      rs61888800) and the efficacy of electroconvulsive therapy (ECT) [change in 
      Montgomery-Asberg Depression Rating Scale (MADRS)]. So far, there are no studies 
      investigating an association between these polymorphisms and the efficacy of ECT. 
      The patient sample included 119 patients with treatment-resistant major 
      depressive disorder who were treated with ECT. BDNF polymorphism rs11030101, but 
      not rs61888800, was associated with a change in the MADRS score. Patients with 
      the TA genotype of rs11030101 were less likely to benefit from ECT compared with 
      patients with the TT genotype (P=0.041). The finding suggests an association 
      between BDNF polymorphism rs11030101 and the efficacy of ECT. Further studies 
      with larger samples will be required to confirm this finding.
FAU - Viikki, Merja L
AU  - Viikki ML
AD  - Department of Psychiatry, Medical School, University of Tampere, Tampere, 
      Finland. merja.viikki@gmail.com
FAU - Jarventausta, Kaija
AU  - Jarventausta K
FAU - Leinonen, Esa
AU  - Leinonen E
FAU - Huuhka, Martti
AU  - Huuhka M
FAU - Mononen, Nina
AU  - Mononen N
FAU - Lehtimaki, Terho
AU  - Lehtimaki T
FAU - Kampman, Olli
AU  - Kampman O
LA  - eng
PT  - Journal Article
PL  - England
TA  - Psychiatr Genet
JT  - Psychiatric genetics
JID - 9106748
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Case-Control Studies
MH  - Depression/genetics/*therapy
MH  - *Electroconvulsive Therapy
MH  - Humans
MH  - Middle Aged
MH  - *Polymorphism, Genetic
EDAT- 2013/03/28 06:00
MHDA- 2013/10/24 06:00
CRDT- 2013/03/28 06:00
PHST- 2013/03/28 06:00 [entrez]
PHST- 2013/03/28 06:00 [pubmed]
PHST- 2013/10/24 06:00 [medline]
AID - 10.1097/YPG.0b013e328360c894 [doi]
PST - ppublish
SO  - Psychiatr Genet. 2013 Jun;23(3):134-6. doi: 10.1097/YPG.0b013e328360c894.