PMID- 23532994
OWN - NLM
STAT- MEDLINE
DCOM- 20130930
LR  - 20220408
IS  - 1930-739X (Electronic)
IS  - 1930-7381 (Linking)
VI  - 21
IP  - 2
DP  - 2013 Feb
TI  - Circulating levels of persistent organic pollutants in relation to visceral and 
      subcutaneous adipose tissue by abdominal MRI.
PG  - 413-8
LID - 10.1002/oby.20267 [doi]
AB  - OBJECTIVE: We and others have shown relationships between circulating levels of 
      persistent organic pollutants (POPs) and different measures of obesity in both 
      cross-sectional and prospective studies. Since viscerally located fat seems to be 
      the most harmful type, we investigated whether plasma POP levels were more 
      closely related to visceral adipose tissue (VAT) than to subcutaneous adipose 
      tissue (SAT). DESIGN AND METHODS: Thousand hundred and sixteen subjects aged 70 
      years were investigated in the Prospective Investigation of the Vasculature in 
      Uppsala Seniors (PIVUS) study; 23 POPs were analyzed using high-resolution gas 
      chromatography/high-resolution mass spectrometry. Abdominal magnetic resonance 
      imaging, measuring VAT and SAT, respectively, was performed in a representative 
      subsample of 287 subjects. RESULTS: The less chlorinated polychlorinated biphenyl 
      (PCB) congeners (105 and 118), and the pesticides 
      dichlorodiphenyldichloroethylene (DDE), hexachlorobenzene (HCB), and 
      trans-nonachlordane (TNC) were positively related to both VAT and SAT, whereas 
      the more highly chlorinated PCBs (153, 156, 157, 169, 170, 180, 194, 206, and 
      209) were inversely related to both VAT and SAT. PCB189 was related to the 
      VAT/SAT ratio in an inverted U-shaped manner (P = 0.0008). CONCLUSIONS: In 
      conclusion, the results were in accordance with our previous studies using waist 
      circumference and fat mass as obesity measure. However, the novel finding that 
      PCB189 was related to the VAT/SAT ratio deserves further investigation since 
      exposure to this PCB congener, which has previously been linked to diabetes 
      development, might thereby play a role in the distribution of abdominal adipose 
      tissue.
CI  - Copyright (c) 2012 The Obesity Society.
FAU - Roos, Vendela
AU  - Roos V
AD  - Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden.
FAU - Ronn, Monika
AU  - Ronn M
FAU - Salihovic, Samira
AU  - Salihovic S
FAU - Lind, Lars
AU  - Lind L
FAU - van Bavel, Bert
AU  - van Bavel B
FAU - Kullberg, Joel
AU  - Kullberg J
FAU - Johansson, Lars
AU  - Johansson L
FAU - Ahlstrom, Hakan
AU  - Ahlstrom H
FAU - Lind, P Monica
AU  - Lind PM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Obesity (Silver Spring)
JT  - Obesity (Silver Spring, Md.)
JID - 101264860
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - 4Z87H0LKUY (Hexachlorobenzene)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Dichlorodiphenyl Dichloroethylene
MH  - Environmental Pollutants/blood
MH  - Female
MH  - Hexachlorobenzene/blood
MH  - Humans
MH  - Hydrocarbons, Chlorinated/blood
MH  - Intra-Abdominal Fat/*drug effects/metabolism
MH  - Linear Models
MH  - *Magnetic Resonance Spectroscopy
MH  - Male
MH  - Obesity/chemically induced/pathology
MH  - Overweight/chemically induced/pathology
MH  - Pesticides/*blood
MH  - Polychlorinated Biphenyls/*blood
MH  - Prospective Studies
MH  - Subcutaneous Fat/*drug effects/metabolism
MH  - Surveys and Questionnaires
MH  - Sweden
EDAT- 2013/03/28 06:00
MHDA- 2013/10/01 06:00
CRDT- 2013/03/28 06:00
PHST- 2011/12/20 00:00 [received]
PHST- 2012/04/20 00:00 [accepted]
PHST- 2013/03/28 06:00 [entrez]
PHST- 2013/03/28 06:00 [pubmed]
PHST- 2013/10/01 06:00 [medline]
AID - 10.1002/oby.20267 [doi]
PST - ppublish
SO  - Obesity (Silver Spring). 2013 Feb;21(2):413-8. doi: 10.1002/oby.20267.