PMID- 23533712
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130328
LR  - 20211021
IS  - 2090-0163 (Print)
IS  - 2090-0171 (Electronic)
IS  - 2090-0171 (Linking)
VI  - 2013
DP  - 2013
TI  - Adult medication-free schizophrenic patients exhibit long-chain omega-3 Fatty 
      Acid deficiency: implications for cardiovascular disease risk.
PG  - 796462
LID - 10.1155/2013/796462 [doi]
LID - 796462
AB  - Deficiency in long-chain omega-3 (LCn - 3) fatty acids, eicosapentaenoic acid 
      (EPA, 20:5n - 3) and docosahexaenoic acid (DHA, 22:6n - 3), has been implicated 
      in the pathoetiology of cardiovascular disease, a primary cause of excess 
      premature mortality in patients with schizophrenia (SZ). In the present study, we 
      determined erythrocyte EPA + DHA levels in adult medication-free patients SZ (n = 
      20) and age-matched healthy controls (n = 24). Erythrocyte EPA + DHA composition 
      exhibited by SZ patients (3.5%) was significantly lower than healthy controls 
      (4.5%, -22%, P = 0.007). The majority of SZ patients (72%) exhibited EPA+DHA 
      levels </=4.0% compared with 37% of controls (Chi-square, P = 0.001). In contrast, 
      the omega-6 fatty acid arachidonic acid (AA, 20:4n - 6) (+9%, P = 0.02) and the 
      AA:EPA + DHA ratio (+28%, P = 0.0004) were significantly greater in SZ patients. 
      Linoleic acid (18:2n - 6) was significantly lower (-12%, P = 0.009) and the 
      erythrocyte 20:3/18:2 ratio (an index of delta6-desaturase activity) was 
      significantly elevated in SZ patients. Compared with same-gender controls, EPA + 
      DHA composition was significantly lower in male (-19%, P = 0.04) but not female 
      (-13%, P = 0.33) SZ patients, whereas the 20:3/18:2 ratio was significantly 
      elevated in both male (+22%, P = 0.008) and female (+22%, P = 0.04) SZ patients. 
      These results suggest that the majority of SZ patients exhibit low LCn - 3 fatty 
      acid levels which may place them at increased risk for cardiovascular morbidity 
      and mortality.
FAU - McNamara, Robert K
AU  - McNamara RK
AD  - Department of Psychiatry, University of Cincinnati College of Medicine, 
      Cincinnati, OH 45219-0516, USA.
FAU - Jandacek, Ronald
AU  - Jandacek R
FAU - Rider, Therese
AU  - Rider T
FAU - Tso, Patrick
AU  - Tso P
FAU - Dwivedi, Yogesh
AU  - Dwivedi Y
FAU - Pandey, Ghanshyam N
AU  - Pandey GN
LA  - eng
GR  - R01 MH056528/MH/NIMH NIH HHS/United States
GR  - R34 MH083924/MH/NIMH NIH HHS/United States
GR  - U24 DK059630/DK/NIDDK NIH HHS/United States
GR  - UL1 TR000077/TR/NCATS NIH HHS/United States
PT  - Journal Article
DEP - 20130227
PL  - Egypt
TA  - Cardiovasc Psychiatry Neurol
JT  - Cardiovascular psychiatry and neurology
JID - 101516142
PMC - PMC3600206
EDAT- 2013/03/28 06:00
MHDA- 2013/03/28 06:01
PMCR- 2013/02/27
CRDT- 2013/03/28 06:00
PHST- 2012/07/20 00:00 [received]
PHST- 2013/01/17 00:00 [accepted]
PHST- 2013/03/28 06:00 [entrez]
PHST- 2013/03/28 06:00 [pubmed]
PHST- 2013/03/28 06:01 [medline]
PHST- 2013/02/27 00:00 [pmc-release]
AID - 10.1155/2013/796462 [doi]
PST - ppublish
SO  - Cardiovasc Psychiatry Neurol. 2013;2013:796462. doi: 10.1155/2013/796462. Epub 
      2013 Feb 27.