PMID- 23533787
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130328
LR  - 20211021
IS  - 2090-3448 (Print)
IS  - 2090-3456 (Electronic)
VI  - 2013
DP  - 2013
TI  - Histological and immunohistochemical revision of hepatocellular adenomas: a 
      learning experience.
PG  - 398308
LID - 10.1155/2013/398308 [doi]
LID - 398308
AB  - Light has been shed on the genotype/phenotype correlation in hepatocellular 
      adenoma (HCA) recognizing HNF1 alpha -inactivated HCA (H-HCA), inflammatory HCA 
      (IHCA), and beta -catenin-activated HCA (b-HCA). We reviewed retrospectively our 
      surgical HCA series to learn how to recognize the different subtypes 
      histopathologically and how to interpret adequately their immunohistochemical 
      staining. From January 1992 to January 2012, 37 patients underwent surgical 
      resection for HCA in our institution. Nine had H-HCA (25%) characterized by 
      steatosis and loss of L-FABP expression; 20 had IHCA (55.5%) showing CRP and/or 
      SAA expression, sinusoidal dilatation, and variable inflammation; and 1 patient 
      had both H-HCA and IHCA. In 5 patients (14%), b-HCA with GS and beta -catenin 
      nuclear positivity was diagnosed, two already with hepatocellular carcinoma. Two 
      cases (5.5%) remained unclassified. One of the b-HCA showed also the H-HCA 
      histological and immunohistochemical characteristics suggesting a subgroup of beta 
      -catenin-activated/HNF1 alpha -inactivated HCA, another b-HCA exhibited the IHCA 
      histological and immunohistochemical characteristics suggesting a subgroup of beta 
      -catenin-activated/inflammatory HCA. Interestingly, three patients had underlying 
      vascular abnormalities. Using the recently published criteria enabled us to 
      classify histopathologically our retrospective HCA surgical series with accurate 
      recognition of b-HCA for which we confirm the higher risk of malignant 
      transformation. We also underlined the association between HCA and vascular 
      abnormalities.
FAU - Fonseca, S
AU  - Fonseca S
AD  - Service d'Anatomie Pathologique, Cliniques Universitaires Saint-Luc, UCL, Avenue 
      Hippocrate, 10, 1200 Brussels, Belgium.
FAU - Hoton, D
AU  - Hoton D
FAU - Dardenne, S
AU  - Dardenne S
FAU - Annet, L
AU  - Annet L
FAU - Hubert, C
AU  - Hubert C
FAU - Godecharles, S
AU  - Godecharles S
FAU - Jouret-Mourin, A
AU  - Jouret-Mourin A
FAU - Reding, R
AU  - Reding R
FAU - Otte, J B
AU  - Otte JB
FAU - Rahier, J
AU  - Rahier J
FAU - Gigot, J F
AU  - Gigot JF
FAU - Sempoux, C
AU  - Sempoux C
LA  - eng
PT  - Journal Article
DEP - 20130228
PL  - United States
TA  - Int J Hepatol
JT  - International journal of hepatology
JID - 101564967
PMC - PMC3603421
EDAT- 2013/03/28 06:00
MHDA- 2013/03/28 06:01
PMCR- 2013/02/28
CRDT- 2013/03/28 06:00
PHST- 2012/10/03 00:00 [received]
PHST- 2013/01/19 00:00 [accepted]
PHST- 2013/03/28 06:00 [entrez]
PHST- 2013/03/28 06:00 [pubmed]
PHST- 2013/03/28 06:01 [medline]
PHST- 2013/02/28 00:00 [pmc-release]
AID - 10.1155/2013/398308 [doi]
PST - ppublish
SO  - Int J Hepatol. 2013;2013:398308. doi: 10.1155/2013/398308. Epub 2013 Feb 28.