PMID- 23534947
OWN - NLM
STAT- MEDLINE
DCOM- 20140121
LR  - 20240503
IS  - 1936-2692 (Electronic)
IS  - 1088-0224 (Print)
IS  - 1088-0224 (Linking)
VI  - 19
IP  - 3
DP  - 2013 Mar 1
TI  - Measuring concurrent oral hypoglycemic and antidepressant adherence and clinical 
      outcomes.
PG  - e85-92
AB  - OBJECTIVES: Many patients experience difficulty in adhering to medication for 
      both physical and mental health. Our objective was to compare selfreported 
      adherence and electronic monitoring of adherence to oral hypoglycemic agents and 
      antidepressants and to examine the relationship of adherence with clinical 
      outcomes. STUDY DESIGN: Primary care-based longitudinal study. METHODS: Adherence 
      was assessed in 180 patients prescribed pharmacotherapy for type 2 diabetes 
      mellitus (T2DM) and depression enrolled in a randomized controlled trial of an 
      integrated intervention for depression and T2DM. Adherence data were collected 
      using self report and electronic monitoring. Glycated hemoglobin (A1C) assays 
      were used to measure glycemic control, and the 9-item patient health 
      questionnaire assessed depression. RESULTS: At 12 weeks, self-reported adherence 
      and electronic monitoring of adherence showed fair agreement (kappa = 0.213, P = 
      .004 for oral hypoglycemic agents and kappa = 0.380, P < .001 for 
      antidepressants). Patients who achieved >80% adherence to oral hypoglycemic 
      agents measured with electronic monitoring were more likely to achieve A1C < 7% 
      compared with patients who did not achieve > 80% adherence at 12 weeks (adjusted 
      odds ratio = 3.52, 95% confidence interval 1.07-11.57). Self-reported adherence 
      to oral hypoglycemic agents was not associated with diabetes outcomes. Measures 
      of adherence for antidepressants were not associated with depression outcomes in 
      models adjusted for potentially influential covariates. CONCLUSIONS: Compared 
      with electronic monitoring of adherence, self-reported adherence tended to 
      overestimate medication adherence. Electronic monitoring of adherence to oral 
      hypoglycemic agents predicted glycemic control, but self-reported adherence did 
      not predict clinical outcomes.
FAU - Bogner, Hillary R
AU  - Bogner HR
AD  - Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, 
      The University of Pennsylvania, 9 Blockley Hall, 423 Guardian Dr, Philadelphia, 
      PA 19104, USA. hillary.bogner@uphs.upenn.edu
FAU - de Vries, Heather F
AU  - de Vries HF
FAU - O'Donnell, Alison J
AU  - O'Donnell AJ
FAU - Morales, Knashawn H
AU  - Morales KH
LA  - eng
GR  - MH082799/MH/NIMH NIH HHS/United States
GR  - R01 MH082799/MH/NIMH NIH HHS/United States
GR  - MH047447/MH/NIMH NIH HHS/United States
GR  - K01 MH073903/MH/NIMH NIH HHS/United States
GR  - MH073903/MH/NIMH NIH HHS/United States
GR  - R01 MH047447/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20130301
PL  - United States
TA  - Am J Manag Care
JT  - The American journal of managed care
JID - 9613960
RN  - 0 (Antidepressive Agents)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Hypoglycemic Agents)
MH  - Administration, Oral
MH  - Antidepressive Agents/administration & dosage/*therapeutic use
MH  - Depression/drug therapy
MH  - Diabetes Mellitus, Type 2/drug therapy
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Hypoglycemic Agents/administration & dosage/*therapeutic use
MH  - Longitudinal Studies
MH  - Medication Adherence/psychology/*statistics & numerical data
MH  - Philadelphia
MH  - Treatment Outcome
PMC - PMC4094025
MID - NIHMS591331
EDAT- 2013/03/29 06:00
MHDA- 2014/01/22 06:00
PMCR- 2014/07/11
CRDT- 2013/03/29 06:00
PHST- 2013/03/29 06:00 [entrez]
PHST- 2013/03/29 06:00 [pubmed]
PHST- 2014/01/22 06:00 [medline]
PHST- 2014/07/11 00:00 [pmc-release]
AID - 88996 [pii]
PST - epublish
SO  - Am J Manag Care. 2013 Mar 1;19(3):e85-92.