PMID- 23535025
OWN - NLM
STAT- MEDLINE
DCOM- 20131223
LR  - 20211021
IS  - 1873-2585 (Electronic)
IS  - 1047-2797 (Print)
IS  - 1047-2797 (Linking)
VI  - 23
IP  - 7
DP  - 2013 Jul
TI  - Adipocytokines as features of the metabolic syndrome determined using 
      confirmatory factor analysis.
PG  - 415-21
LID - S1047-2797(13)00055-0 [pii]
LID - 10.1016/j.annepidem.2013.03.001 [doi]
AB  - PURPOSE: Confirmatory factor analysis (CFA) was used to test the hypothesis 
      whether adipocytokines are associated with the risk factor cluster that 
      characterizes the metabolic syndrome (MetS). METHODS: Data from 134 nondiabetic 
      subjects were analyzed using CFA. Insulin sensitivity (SI) was quantified using 
      intravenous glucose tolerance tests, visceral fat area by computed tomography and 
      fasting high-density lipoprotein, triglycerides, monocyte chemoattractant 
      protein-1 (MCP-1), serum amyloid A (SAA), tumor necrosis factor (TNF)-alpha, 
      adiponectin, resistin, leptin, interleukin (IL)-6, C-reactive protein (CRP), and 
      plasminogen activator inhibitor (PAI)-1 were measured. RESULTS: The basic model 
      representing the MetS included six indicators comprising obesity, SI, lipids, and 
      hypertension, and demonstrated excellent goodness of fit. Using multivariate 
      analysis, MCP-1, SAA, and TNF-alpha were not independently associated with any of the 
      MetS variables. Adiponectin, resistin, leptin, CRP, and IL-6 were associated with 
      at least one of the risk factors, but when added to the basic model decreased all 
      goodness-of-fit parameters. PAI-1 was associated with all cardiometabolic factors 
      and improved goodness-of-fit compared with the basic model. CONCLUSIONS: Addition 
      of PAI-1 increased the CFA model goodness of fit compared with the basic model, 
      suggesting that this protein may represent an added feature of the MetS.
CI  - Published by Elsevier Inc.
FAU - Smits, Mark M
AU  - Smits MM
AD  - Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA 
      Puget Sound Health Care System, Seattle, WA 98108, USA.
FAU - Woudstra, Pier
AU  - Woudstra P
FAU - Utzschneider, Kristina M
AU  - Utzschneider KM
FAU - Tong, Jenny
AU  - Tong J
FAU - Gerchman, Fernando
AU  - Gerchman F
FAU - Faulenbach, Mirjam
AU  - Faulenbach M
FAU - Carr, Darcy B
AU  - Carr DB
FAU - Aston-Mourney, Kathryn
AU  - Aston-Mourney K
FAU - Chait, Alan
AU  - Chait A
FAU - Knopp, Robert H
AU  - Knopp RH
FAU - Meigs, James B
AU  - Meigs JB
FAU - Boyko, Edward J
AU  - Boyko EJ
FAU - Kahn, Steven E
AU  - Kahn SE
LA  - eng
GR  - DK-080140/DK/NIDDK NIH HHS/United States
GR  - M01 RR000037/RR/NCRR NIH HHS/United States
GR  - DK-035816/DK/NIDDK NIH HHS/United States
GR  - K24 DK080140/DK/NIDDK NIH HHS/United States
GR  - P30 DK035816/DK/NIDDK NIH HHS/United States
GR  - DK-017047/DK/NIDDK NIH HHS/United States
GR  - P30 DK017047/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20130325
PL  - United States
TA  - Ann Epidemiol
JT  - Annals of epidemiology
JID - 9100013
RN  - 0 (Adipokines)
RN  - 0 (Blood Glucose)
RN  - 0 (Lipids)
RN  - 0 (Plasminogen Activator Inhibitor 1)
RN  - 0 (Triglycerides)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adipokines/*blood
MH  - Adult
MH  - Aged
MH  - Blood Glucose/analysis
MH  - Body Mass Index
MH  - Factor Analysis, Statistical
MH  - Female
MH  - Humans
MH  - Insulin Resistance
MH  - Lipids/blood
MH  - Male
MH  - Metabolic Syndrome/blood/complications
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Obesity/blood
MH  - Plasminogen Activator Inhibitor 1/blood
MH  - Risk Factors
MH  - Tomography Scanners, X-Ray Computed
MH  - Triglycerides/blood
MH  - Tumor Necrosis Factor-alpha/blood
PMC - PMC3778191
MID - NIHMS513445
EDAT- 2013/03/29 06:00
MHDA- 2013/12/24 06:00
PMCR- 2014/07/01
CRDT- 2013/03/29 06:00
PHST- 2012/08/22 00:00 [received]
PHST- 2013/02/21 00:00 [revised]
PHST- 2013/03/06 00:00 [accepted]
PHST- 2013/03/29 06:00 [entrez]
PHST- 2013/03/29 06:00 [pubmed]
PHST- 2013/12/24 06:00 [medline]
PHST- 2014/07/01 00:00 [pmc-release]
AID - S1047-2797(13)00055-0 [pii]
AID - 10.1016/j.annepidem.2013.03.001 [doi]
PST - ppublish
SO  - Ann Epidemiol. 2013 Jul;23(7):415-21. doi: 10.1016/j.annepidem.2013.03.001. Epub 
      2013 Mar 25.