PMID- 23535294
OWN - NLM
STAT- MEDLINE
DCOM- 20130829
LR  - 20200930
IS  - 1944-7884 (Electronic)
IS  - 1525-4135 (Linking)
VI  - 63
IP  - 3
DP  - 2013 Jul 1
TI  - Reduction in perinatal HIV infections in KwaZulu-Natal, South Africa, in the era 
      of more effective prevention of mother to child transmission interventions 
      (2004-2012).
PG  - 410-5
LID - 10.1097/QAI.0b013e3182926931 [doi]
AB  - OBJECTIVE: To describe a trend in perinatal HIV transmission associated with the 
      implementation of rapidly changing prevention of mother to child transmission 
      (PMTCT) interventions from 2004 to 2012. METHOD: Retrospective analysis of infant 
      HIV polymerase chain reaction results of infants from 2004 to 2012 archived from 
      a Laboratory Information System. SETTING: KwaZulu-Natal, South Africa. MAIN 
      OUTCOME MEASURE: HIV infection in infants aged 4-8 weeks. RESULTS: The proportion 
      of 4- to 8-week-old infants who tested HIV polymerase chain reaction positive 
      decreased significantly (P < 0.0001) from 27.5% in 2004 to 2.9% in 2012. The 
      reduction rates in perinatal HIV infections in 4- to 8-week-old HIV-exposed 
      infants decreased significantly (P < 0.0001) by 48.7% following single-dose 
      nevirapine (sdNVP) (2005 to April 2008), 68.4% with zidovudine from 28 weeks and 
      sdNVP together with triple antiretroviral therapy for women with CD4 cell count < 
      200 cells/mm(3) (May 2008-April 2010), and 89.5% with zidovudine from 14 weeks, 
      sdNVP, and triple antiretroviral therapy for women with CD4(+) cell count < 350 
      cells/mm(3) (May 2010-December 2012). CONCLUSIONS: We show an almost 10-fold 
      reduction in mother to child transmission from 2004 to 2012 in infants aged 4-8 
      weeks during a rapid implementation of more complex and robust PMTCT 
      interventions. The significant reductions in mother to child transmission in the 
      South African PMTCT program are encouraging for a middle-income country with the 
      second highest antenatal HIV prevalence in the world.
FAU - Moodley, Pravi
AU  - Moodley P
AD  - Department of Virology, National Health Laboratory Service and Nelson R. Mandela 
      School of Medicine, University of KwaZulu-Natal, Durban, South Africa. 
      moodleyp36@ukzn.ac.za
FAU - Parboosing, Raveen
AU  - Parboosing R
FAU - Moodley, Dhayendre
AU  - Moodley D
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Acquir Immune Defic Syndr
JT  - Journal of acquired immune deficiency syndromes (1999)
JID - 100892005
RN  - 0 (Anti-HIV Agents)
SB  - IM
MH  - Anti-HIV Agents/therapeutic use
MH  - Female
MH  - HIV Infections/drug therapy/epidemiology/*prevention & control/*transmission
MH  - Humans
MH  - Infant
MH  - Infectious Disease Transmission, Vertical/*prevention & control
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/*drug therapy
MH  - Retrospective Studies
MH  - South Africa/epidemiology
EDAT- 2013/03/29 06:00
MHDA- 2013/08/30 06:00
CRDT- 2013/03/29 06:00
PHST- 2013/03/29 06:00 [entrez]
PHST- 2013/03/29 06:00 [pubmed]
PHST- 2013/08/30 06:00 [medline]
AID - 10.1097/QAI.0b013e3182926931 [doi]
PST - ppublish
SO  - J Acquir Immune Defic Syndr. 2013 Jul 1;63(3):410-5. doi: 
      10.1097/QAI.0b013e3182926931.