PMID- 23535307
OWN - NLM
STAT- MEDLINE
DCOM- 20131022
LR  - 20191112
IS  - 1347-3352 (Electronic)
IS  - 1345-8957 (Linking)
VI  - 62
IP  - 4
DP  - 2013
TI  - Oxidized trilinoleate and tridocosahexaenoate induce pica behavior and change 
      locomotor activity.
PG  - 207-12
AB  - Pica behavior, a behavior that is characterized by eating a nonfood material such 
      as kaolin and relates to the degree of discomfort in animals, and the variations 
      of locomotor activity of rats after eating deteriorated fat and oil extracted 
      from instant noodles were examined in our previous study. The result shows that 
      oxidized fat and oil with at least 100 meq/kg in peroxide value (PV) increase 
      pica behavior and decrease locomotor activity. In the present study, the same two 
      behaviors were measured using autoxidized trilinoleate (tri-LA) and 
      tridocosahexaenoate (tri-DHA) as a model of vegetable and fish oil, respectively, 
      to compare fatty acid differences against the induction of two behaviors. The 
      oxidized levels of tri-LA and tri-DHA were analyzed with PV and p-anisidine value 
      (AnV), the method to analyze secondary oxidized products. The oxidation levels of 
      respective triacylglycerol (TAG) samples were carefully adjusted to make them 
      having almost the same PV and AnV. As the results, 600 or more meq/kg in PV of 
      both TAGs significantly increased the consumption of kaolin pellets compared to 
      the control group. Furthermore, 300 or more meq/kg in PV of tri-LA and 200 or 
      more meq/kg in PV of tri-DHA demonstrated significant decrease in locomotor 
      activity compared to control group. These results would indicate that the 
      oxidized TAG having the same PV and/or AnV would induce the same type of pica 
      behavior and locomotor activity. Furthermore, that the structure of oxidized 
      products might not be important and the amount of hydroperoxide group and/or 
      aldehyde group in deteriorated fats and oils might affect the pica behavior and 
      locomotor activity were thought.
FAU - Kitamura, Fuki
AU  - Kitamura F
AD  - Department of Food Science and Technology, Tokyo University of Marine Science and 
      Technology, Tokyo, Japan.
FAU - Watanabe, Hiroyuki
AU  - Watanabe H
FAU - Umeno, Aya
AU  - Umeno A
FAU - Yoshida, Yasukazu
AU  - Yoshida Y
FAU - Kurata, Kenji
AU  - Kurata K
FAU - Gotoh, Naohiro
AU  - Gotoh N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - J Oleo Sci
JT  - Journal of oleo science
JID - 101175339
RN  - 0 (Aniline Compounds)
RN  - 0 (Fatty Acids, Unsaturated)
RN  - 0 (Lipid Peroxides)
RN  - 0 (Triglycerides)
RN  - 24H4NWX5CO (Kaolin)
RN  - 25167-62-8 (Docosahexaenoic Acids)
RN  - 575917SNR4 (4-anisidine)
RN  - V5LJ52OGS7 (trilinolein)
SB  - IM
MH  - Aniline Compounds/metabolism
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Docosahexaenoic Acids/administration & dosage/*pharmacology
MH  - Fatty Acids, Unsaturated/administration & dosage/*pharmacology
MH  - Feeding Behavior/drug effects
MH  - Kaolin/pharmacology
MH  - Lipid Peroxides/metabolism
MH  - Male
MH  - Motor Activity/*drug effects
MH  - Oxidation-Reduction/drug effects
MH  - Pica/*pathology/*physiopathology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Triglycerides/administration & dosage/*pharmacology
EDAT- 2013/03/29 06:00
MHDA- 2013/10/23 06:00
CRDT- 2013/03/29 06:00
PHST- 2013/03/29 06:00 [entrez]
PHST- 2013/03/29 06:00 [pubmed]
PHST- 2013/10/23 06:00 [medline]
AID - DN/JST.JSTAGE/jos/62.207 [pii]
AID - 10.5650/jos.62.207 [doi]
PST - ppublish
SO  - J Oleo Sci. 2013;62(4):207-12. doi: 10.5650/jos.62.207.