PMID- 23535373
OWN - NLM
STAT- MEDLINE
DCOM- 20130628
LR  - 20161125
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 434
IP  - 2
DP  - 2013 May 3
TI  - Exercise ameliorates cognition impairment due to restraint stress-induced 
      oxidative insult and reduced BDNF level.
PG  - 245-51
LID - S0006-291X(13)00465-8 [pii]
LID - 10.1016/j.bbrc.2013.02.111 [doi]
AB  - We assessed whether chronic treadmill exercise attenuated restraint 
      stress-induced cognition impairment. Although serum corticosterone was not 
      significantly altered by exercise, the restraint-induced increases in hippocampal 
      malondialdehyde (MDA) and 4-hydroxynonenal (HNE) were reduced by chronic 
      exercise. The exercise paradigm also reversed stress-induced reductions in 
      brain-derived neurotrophic factor (BDNF), which increased cAMP response 
      element-binding protein (CREB) and AKT activation. We verified the relationship 
      between oxidative stress and BDNF signaling by treating primary hippocampal 
      cultures with hydrogen peroxide (H2O2), which reduced BDNF and phosphorylated 
      CREB and AKT (p-CREB, p-AKT) in a dose-dependent manner. Notably, pretreatment 
      with N-acetylcysteine (NAC) reversed these decreases in a dose-dependent manner. 
      These findings suggest that chronic exercise can ameliorate repeated 
      stress-induced cognitive impairment by detoxifying reactive oxygen species (ROS) 
      in the hippocampus and activating BDNF signaling.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Kwon, Dong-Ho
AU  - Kwon DH
AD  - Department of Sports and Leisure, Sungshin Women's University, Dongseon 3-ga, 
      Seoungbuk-Gu, Seoul 136-742, South Korea.
FAU - Kim, Bum-Soo
AU  - Kim BS
FAU - Chang, Hyukki
AU  - Chang H
FAU - Kim, Young-In
AU  - Kim YI
FAU - Jo, Sangmee Ahn
AU  - Jo SA
FAU - Leem, Yea-Hyun
AU  - Leem YH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130325
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Aldehydes)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Reactive Oxygen Species)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - BBX060AN9V (Hydrogen Peroxide)
RN  - K1CVM13F96 (4-hydroxy-2-nonenal)
RN  - W980KJ009P (Corticosterone)
RN  - WYQ7N0BPYC (Acetylcysteine)
SB  - IM
MH  - Acetylcysteine/pharmacology
MH  - Aldehydes/metabolism
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cognition/drug effects/*physiology
MH  - Cognition Disorders/metabolism/pathology/*prevention & control
MH  - Corticosterone/blood
MH  - Dose-Response Relationship, Drug
MH  - Exercise Test/methods
MH  - Hippocampus/drug effects/metabolism/pathology
MH  - Hydrogen Peroxide/pharmacology
MH  - Immunohistochemistry
MH  - Male
MH  - Malondialdehyde/metabolism
MH  - Maze Learning/drug effects/physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - *Oxidative Stress
MH  - Phosphorylation
MH  - *Physical Conditioning, Animal
MH  - Primary Cell Culture
MH  - Reactive Oxygen Species/metabolism
MH  - Restraint, Physical/methods
MH  - Signal Transduction
MH  - Stress, Psychological/metabolism/*pathology
EDAT- 2013/03/29 06:00
MHDA- 2013/07/03 06:00
CRDT- 2013/03/29 06:00
PHST- 2013/02/06 00:00 [received]
PHST- 2013/02/25 00:00 [accepted]
PHST- 2013/03/29 06:00 [entrez]
PHST- 2013/03/29 06:00 [pubmed]
PHST- 2013/07/03 06:00 [medline]
AID - S0006-291X(13)00465-8 [pii]
AID - 10.1016/j.bbrc.2013.02.111 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2013 May 3;434(2):245-51. doi: 
      10.1016/j.bbrc.2013.02.111. Epub 2013 Mar 25.