PMID- 23535396
OWN - NLM
STAT- MEDLINE
DCOM- 20130903
LR  - 20190911
IS  - 1880-3989 (Electronic)
IS  - 0388-1350 (Linking)
VI  - 38
IP  - 2
DP  - 2013
TI  - Can intermediate-frequency magnetic fields affect memory function-related gene 
      expressions in hippocampus of C57BL/6J mice?
PG  - 169-76
AB  - Recently, a cooking appliance based on the principle of electromagnetic induction 
      has come to be used domestically on a widespread basis; this induction heating 
      cooking hob mainly generates intermediate-frequency magnetic fields (IF-MF). 
      However, whether electromagnetic fields originating from household appliances 
      represent a health risk remains uncertain. We investigated the effect of IF-MF on 
      the expressions of memory function-related genes and related transduction 
      molecules in the mouse hippocampus. Male and female C57BL/6J mice were allotted 
      to a control (sham-exposed), an exposure, or a recovery (one week after exposure) 
      group and were exposed to IF-MF (21 kHz, 3.8 mT) one hour per day for 2 weeks. 
      Twenty-four hour after final exposure, the expression levels of memory 
      function-related genes and the mRNA levels for signal transduction pathway 
      molecules in the hippocampi were examined using real-time RT-PCR. The relative 
      mRNA expression levels of the N-methyl-D aspartate (NMDA) receptor subunits NR1, 
      NR2A, and NR2B as well as transcription factors (calcium/calmodulin-dependent 
      protein kinase (CaMK) -IV, cyclic AMP responsive element binding protein (CREB) 
      -1) and neurotrophins (nerve growth factor (NGF), and brain-derived neurotrophic 
      factors (BDNF)) were not significantly altered in the IF-MF-exposed mice. We also 
      examined the morphology of the hippocampus using a histological analysis, but no 
      changes in the IF-MF-exposed mice were seen. This is the first in vivo study to 
      show that IF-MF exposure did not affect the expression levels of memory 
      function-related genes in the hippocampus of C57BL/6J mice. The present findings 
      suggest that IF-MF exposure may not affect cognitive function in the present 
      animal model.
FAU - Win-Shwe, Tin-Tin
AU  - Win-Shwe TT
AD  - Center for Environmental Health Sciences, National Institute for Environmental 
      Studies, Ibaraki, Japan.
FAU - Ohtani, Shin
AU  - Ohtani S
FAU - Ushiyama, Akira
AU  - Ushiyama A
FAU - Fujimaki, Hidekazu
AU  - Fujimaki H
FAU - Kunugita, Naoki
AU  - Kunugita N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - J Toxicol Sci
JT  - The Journal of toxicological sciences
JID - 7805798
RN  - 0 (Nerve Growth Factors)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - Female
MH  - *Gene Expression
MH  - Hippocampus/*physiology
MH  - Magnetic Fields/*adverse effects
MH  - Male
MH  - *Memory
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Models, Animal
MH  - Nerve Growth Factors/genetics
MH  - RNA, Messenger/*metabolism
MH  - Receptors, N-Methyl-D-Aspartate/genetics
MH  - Signal Transduction/*genetics
MH  - Transcription Factors/genetics
EDAT- 2013/03/29 06:00
MHDA- 2013/09/04 06:00
CRDT- 2013/03/29 06:00
PHST- 2013/03/29 06:00 [entrez]
PHST- 2013/03/29 06:00 [pubmed]
PHST- 2013/09/04 06:00 [medline]
AID - DN/JST.JSTAGE/jts/38.169 [pii]
AID - 10.2131/jts.38.169 [doi]
PST - ppublish
SO  - J Toxicol Sci. 2013;38(2):169-76. doi: 10.2131/jts.38.169.