PMID- 23536571
OWN - NLM
STAT- MEDLINE
DCOM- 20140714
LR  - 20220318
IS  - 1933-7205 (Electronic)
IS  - 1933-7191 (Linking)
VI  - 20
IP  - 10
DP  - 2013 Oct
TI  - Regression of endometrial implants by resveratrol in an experimentally induced 
      endometriosis model in rats.
PG  - 1230-6
LID - 10.1177/1933719113483014 [doi]
AB  - OBJECTIVE: To evaluate the effect of resveratrol on an experimentally induced 
      endometriosis rat model. STUDY DESIGN: After endometriotic implants were 
      surgically formed, rats were randomly divided into 2 groups as control group 
      (saline treated, n = 6) and resveratrol group (10 mg/kg/d, n = 6). The 
      inflammatory markers and histopathological changes were assessed at the end of 
      the treatment period. Results Our results showed (1) significant reduction in the 
      implant size (P < .0005); (2) significantly decreased levels of vascular 
      endothelial growth factor (VEGF) in the peritoneal fluid and plasma (P < .005); 
      and monocyte chemotactic protein 1 (MCP-1) in the peritoneal fluid (P < .05), (3) 
      highly significant suppression of VEGF expression in the endometriotic tissue (P 
      < .0005); and (4) considerable histological changes in the endometriotic foci 
      following resveratrol treatment. CONCLUSION: Resveratrol appears to be effective 
      on the development of endometriosis through its antiangiogenic and 
      anti-inflammatory properties. Future studies with different doses of resveratrol 
      might provide more comprehensive results regarding the treatment of 
      endometriosis.
FAU - Ergenoglu, Ahmet Mete
AU  - Ergenoglu AM
AD  - 1Department of Obstetrics and Gynaecology, Ege University School of Medicine, 
      Izmir, Turkey.
FAU - Yeniel, Ahmet Ozgur
AU  - Yeniel AO
FAU - Erbas, Oytun
AU  - Erbas O
FAU - Aktug, Huseyin
AU  - Aktug H
FAU - Yildirim, Nuri
AU  - Yildirim N
FAU - Ulukus, Murat
AU  - Ulukus M
FAU - Taskiran, Dilek
AU  - Taskiran D
LA  - eng
PT  - Journal Article
DEP - 20130327
PL  - United States
TA  - Reprod Sci
JT  - Reproductive sciences (Thousand Oaks, Calif.)
JID - 101291249
RN  - 0 (Stilbenes)
RN  - Q369O8926L (Resveratrol)
SB  - IM
MH  - Animals
MH  - *Disease Models, Animal
MH  - Endometriosis/*drug therapy/*pathology
MH  - Endometrium/drug effects/*pathology
MH  - Female
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Remission Induction/methods
MH  - Resveratrol
MH  - Stilbenes/pharmacology/*therapeutic use
OTO - NOTNLM
OT  - MCP-1
OT  - TNF-alpha
OT  - VEGF
OT  - cytokines
OT  - endometriosis
OT  - resveratrol
EDAT- 2013/03/29 06:00
MHDA- 2014/07/16 06:00
CRDT- 2013/03/29 06:00
PHST- 2013/03/29 06:00 [entrez]
PHST- 2013/03/29 06:00 [pubmed]
PHST- 2014/07/16 06:00 [medline]
AID - 1933719113483014 [pii]
AID - 10.1177/1933719113483014 [doi]
PST - ppublish
SO  - Reprod Sci. 2013 Oct;20(10):1230-6. doi: 10.1177/1933719113483014. Epub 2013 Mar 
      27.